The genetic difference between both strains is the lymphopenia (lyp) gene. Intrathymic tolerance mechanisms are important to prevent autoimmunity, and next to thymus epithelial cells, thymus APC play a prominent part in this tolerance. We here embarked on a study to detect defects in thymus APC ...
In addition to their speculated role in CRC progression, pks islands serve as virulence factors with clinical implica- tions, contributing to systemic infection, neonatal men- ingitis, and lymphopenia, according to various studies [31–33]. In this study, we performed whole-genome sequencing (...
Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sar- coidosis patients correlates with severe disease manifestations. PLoS One. 2010;5(2):e9088. https://doi.org/10.1371/journal.pone.0009088. Erratum in: PLoS One. 2010;5(2). https:/...
in Ig-SC in the patient's MNL as compared to normal control MNL (Table 3). Although the patient's mean total circulatingWBC was within the normal range for age, his WBC differentials consistently demonstrated absolute lymphopenia and often showed a relative monocytosis. Preparations of his MNL...
LymphopeniaFever of Unknown OriginEnlargement of lymph nodes结节病肉芽肿淋巴细胞减少发热原因不明Fever of unknown origin (FUO) is both a clinical and a diagnostic challenge. Furthermore, an FUO case with isolated marrow noncaseating granuloma can further confound diagnosis. However, these two findings...
Negative impact of persistent lymphopenia on patient and graft survival was significant regardless of type of intestinal graft. Infection leading to mortality occurred more frequently in the persistent lymphopenia group (43% vs. 24%). Trend of post-transplant ALC may be a strong predictive marker ...
Based on the detected lymphopenia, she was tested for COVID-19 and was positive. The cerebrospinal fluid analysis showed no abnormalities, while also a repeated head computed tomography was similarly normal. The patient received no specialized medical treatment, and after 6 days, she was discharged...
In one family, two siblings with a stop-codon COPZ1 mutation (NP_057141:p.Gln141Ter) suffered from CN, lymphopenia, anemia, thrombocytopenia, and syndromic organ involvement, including hepatosplenomegaly, atypical autism with mental retardation, varying degrees of bone defects, and dermatitis. An ...
Intensive chemotherapy for acute leukemia is also profoundly immunosuppressive and can be complicated with life-threatening infections, usually associated with neutropenia and prolonged lymphopenia in the post-bone marrow transplant setting. Isolated, acquired immunoglobulin deficiency that occurs during treatment...
Intensive chemotherapy for acute leukemia is also profoundly immunosuppressive and can be complicated with life-threatening infections, usually associated with neutropenia and prolonged lymphopenia in the post-bone marrow transplant setting. Isolated, acquired immunoglobulin deficiency that occurs during treatment...