Wang X, Ding J, Meng LH (2015) PI3K isoform-selective inhibitors: next- generation targeted cancer therapies. Acta Pharmacol Sin 36(10): 1170-1176.咱12暂 Wang X, Ding J, Meng LH. PI3K isoform -selective inhibitors: next -generation targeted cancer therapies [J]. Acta Pharmacol Sin, 2015...
Therefore, the development of isoform-selective compounds represents an effective approach towards understanding the similarities and differences of CRY1 and CRY2 by controlling each isoform individually. We conducted phenotypic screenings of circadian clock modulators, and identified KL101 and TH301 that ...
Therefore, isoform-selective HDAC inhibitors are of great interest, not only as tools for probing the biological functions of the isoforms, but also as candidate therapeutic agents with few side effects. In this review, we cover isoformselective HDAC inhibitors, including their biochemical and ...
(1S,3fi)-ACPD,L-CCG-I are described.Based on the structure of αM4CPG several new conformationally constrained analogues are design ed and synthesized.Among them APICA is a selective antagonist for group II mGluRs.Also,a new benzolactam-V8 analogue is found to have better isoform-selectivity...
et al. Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model. Neuropsychopharmacol. 44, 324–333 (2019). https://doi.org/10.1038/s41386-018-0150-5 Download citation Received26 January 2018 Revised07 June 2018 ...
Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter. Whitehead Maria A,Bombardieri... Whitehead,Maria,A.,... - 《Biochemical Journal》 被引量: 30发表: 2012年 Isoform-selective induction of human p110 delta PI3K expressio...
PI3K inhibitors. Coverage is given for those disclosed PI3K isoform-selective inhibitors that have entered clinical trials in oncology, regardless of their current status. Where possible based on existing information, a focus is placed on discussion of potential structural rationale for isoform ...
Here, in an attempt to identify isoform-selective inhibitors, a large compound library containing 2,703,000 compounds retrieved from Otava database was screened against class I HDACs by exhaustive approach of structure-based virtual screening using rDOCK and Autodock Vina. A total of 41 compounds...
Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter. Whitehead Maria A,Bombardieri... Whitehead,Maria,A.,... - 《Biochemical Journal》 被引量: 30发表: 2012年 Isoform-selective induction of human p110 delta PI3K expressio...
作者: isoform-Selective Phosphatidylinositol3-Kinase Inhibition in Cancer.