Human pluripotent stem-cell-derived islets (hPSC-islets) are a promising cell resource for diabetes treatment1,2. However, this therapeutic strategy has not been systematically assessed in large animal models physiologically similar to humans, such as no
et al. Deciphering tacrolimus-induced toxicity in pancreatic β cells. Am. J. Transplant. 17, 2829–2840 (2017). Article PubMed Google Scholar Gruessner, R. W. & Gruessner, A. C. What defines success in pancreas and islet transplantation—insulin independence or prevention of hypoglycemia?
Most of the cells present in the pancreas are responsible for making an important juice required in the process of breaking down ingested food. The...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our e...
We and others have also identified some age-related DNA methylation changes in human islets, skeletal muscle, adipose tissue, brain and blood cells3,10–18. Furthermore, epigenetic changes are associated with islet dysfunction and hyperglycaemia in aging rats19,20. However, it remains unknown if ...
Experiments of this kind are therefore difficult to interpret, and, indeed, the results from many of these studies are contradictory [25]. The more recent studies suggest that the removal of melatonin by pinealectomy in rodents leads to an increase in plasma glucose levels and a decrease in ...
However, in some endocrine glands, if granules are produced in excessive quantities, they may be destroyed by the intracellular bodies termed lysozomes. In the case of the beta cell, there are important variations in this process and what distinguishes the beta cells of the islets of Langerhans...