MAN,' 'ISLE OF(anc.Mona), a dominion of the crown of England, in the Irish Sea. (For map, see England, section I.) It is about 33 m. long by about 1 2 broad in the broadest part. Its general form resembles that of an heraldic lozenge, though its outline is very irregular, be...
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After the death of Somerled in 1164, Arran and Bute were ruled by his son Angus. In 1237, the Scottish isles broke away completely from the Isle of Man and became an independent kingdom. After the indecisive Battle of Largs between the kingdoms of Norway and Scotland in 1263, Haakon ...
reports military personnel who died between 3rd September 1939 and 31st December 1947, if their death was caused by their wartime service. This includes those who served in the Home Guard and Merchant Navy. Deaths of members of emergency services such as the Auxiliary Fire Service or Air Raid ...
The study required approximately 400 death events to achieve 82% power to detect an HR of 0.75 at a 0.025 significance level (1-sided) for the primary end point. If OS in the all-randomized population proved significant, OS in the subset of patients with a PD-L1 combined positive...
Background Many patients do not respond or eventually relapse on treatment with programmed cell death protein-1 (PD-1)/programmed death-ligand 1 (PD-L1) checkpoint inhibitors due to secondary or acquired resistance; therefore, there is a need to investigate novel PD-1/PD-L1 inhibitors.Methods ...
The devastation of Hurricanes Irma and Maria made clear, for those not yet aware, that the problem is not merely philosophical; it is literally a matter of life and death. We’ll never know the exact toll, but a recent Harvard University study estimates that nearly 5,000 Puerto Ricans died...