2 College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Korea. 3 Vollum Institute, Portland, Oregon 97239, USA. 4 Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. 5 Department ...
The LIM homeodomain (LIM-HD) transcription factor Isl1 was originally found to function as an insulin gene enhancer binding protein [21]. Isl1 is comprised of two tandem LIM domains and a homeodomain. The homeodomain, with its helix-turn-helix structure, binds to regulatory DNA sequences of ...