The purpose of this randomized trial was to confirm drug safety and to obtain preliminary efficacy data on Cervene (nalmefene), an opioid antagonist with relative 魏 receptor selectivity, for the treatment of acute ischemic stroke. Patients were treated for 24 hours with either intravenous Cervene...
Tissue plasminogen activator (tPA) has been shown to improve 3-month outcome in stroke patients treated within 3 hours of symptom onset. The costs associated with this new treatment will be a factor in determining the extent of its utilization. Data from the NINDS rt-PA Stroke Trial and the...
Additionally, treatment with MSC secretome ameliorated proximal tubule damage, highlighting its potential as a viable therapeutic option for targeting AKI.Background Ischemia/reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI) and can even result in kidney failure after ...
atherosclerosis, lacunar, other causes, and cryptogenic strokes [2]. The primary value of the classification of patients with ischemic stroke lies in a better treatment decision-making process. Different subtypes
The incidence of ischemic stroke is highest in the elderly population, representing one of the most common causes of disability and mortality worldwide. Over the past decades, a tremendous amount of research has been undertaken into developing effective therapeutic strategies for the treatment of ...
Recently, dECM medical devices for ICM treatment have been approved for clinical use or studied in clinical trials, exhibiting considerable translation potential. Cells, growth factors and other bioactive agents have been incorporated with different dECM materials to improve the therapeutic outcomes. In...
Rothwell PM, Giles MF, Chandratheva A, et al; Early use of Existing Preventive Strategies for Stroke (EXPRESS) study. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison...
TMSB4 treatment is already being used to promote wound repair in skin, cornea, and heart in a series of ongoing clinical trials30. In the heart, studies have shown that TMSB4 stimulates the formation of new cardiomyocytes, which originate from the epicardial layer31, and promotes ...
Ischemic stroke Females 54.3 1.48 (1.30, 1.68) 6.37 0.53 0.22 Males 78.1 1.19 (1.06, 1.35) 6.85 0.58 0.13 Waist-to-height ratio was categorized into binary using a cutoff value of 0.5. Model was stratified by region, age group, education, and ethnicity and adjusted for deprivation, smoking...
Currently there is no in vitro diagnostic test for acute ischemic stroke (AIS), yet rapid diagnosis is crucial for effective thrombolytic treatment. We previously demonstrated the utility of CD8(+) T-cells’ mRNA expression for AIS detection; however extracellular vesicles (EVs) were not evaluated...