生活质量终点将单独呈现。 Results:5179 participants were randomized. Participants were 64 years old (median), 23% women, 34% 1726 nonwhite, 16% Hispanic, 41% diabetic, and 90% with a history of angina. The qualifying stress test modality was stress imaging in 3909 (75%); the remainder were...
Determines whether elevated cardiac troponin I (cTnI) in patients with unstable angina predict ischemia on stress testing. Comparison of incidence of death and myocardial infarctions; Possible reasons to explain the association of cTnI with stress test results.Fearon...
The toxicity of the free radicals and peroxynitrite results from their modification of macromolecules, especially DNA, and from the resulting induction of apoptotic and necrotic pathways. The mode of cell death that prevails probably depends on the severity and precise nature of the ischemic injury. ...
We investigated the relationship of inducible myocardial ischemia on SPECT stress perfusion imaging to angina reported with routine daily activities during the previous four weeks (N = 788) and to angina reported during an exercise stress test (N = 371) in individuals ...
Based on the log-normalized data, mutual nearest neighbors were used to reduce dimensionality after the elimination of batch effects with the R package (version 3.0). The dimension-reduced results were then visualized using a t-distributed stochastic neighbor embedding (t-SNE) plot. To optimize cl...
These results suggest that TRAF2 protects against cerebral ischemic damage by suppressing necroptotic cell death following experimental stroke. Fig. 6: Administration of nec-1 abrogated the exacerbating effect of TRAF2 knockdown on ischemia-induced cell death following MCAO. a Representative images of ...
The Figure shows the breakdown of patients and their MRI status depending on whether results of the neurologic examination were normal or not. eFigures 2 and 3 in the Supplement show the MRI status according to patient-determined complete symptom resolution. More important, there was a similar ...
(n = 3). *p < 0.05 vs. the empty vector group.cChIP assay results for three sites were presented on agarose gels, grouped as input, positive and Sp1 (n = 3).d,eCells transfected with two Del plasmids were used in the luciferase assay and the results were normalized to...
Salidroside has anti-inflammatory, antioxidant and hepatoprotective properties. However, its effect on hepatic ischemia–reperfusion injury (IRI), an unavoidable side effect associated with liver transplantation, remains undefined. Here, we aimed to dete
Interestingly, induction of mitochondrial PINK1 accumulation in response to RhoA signaling is neither mediated through its transcriptional upregulation nor dependent on depolarization of the mitochondrial membrane, the canonical mechanism for PINK1 accumulation. Instead, our results reveal that RhoA signaling ...