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14 If the Taq1 'A1' allele is in linkage disequilibrium with a mutation that decreases the expression of the D2 receptor gene, it is conceivable that subjects with the A1 allele might be predisposed to behaviors which stimulate dopamine transmission, such as alcoholism or substance abuse. In ...
Molecular PsychiatryDuaux E, Gorwood P, Griffon N, Bourdel MC, Sautel F, Sokoloff P, Schwartz JC, Ades J, Loo H, Poirier MF (1998) Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence. Molecular Psychiatry. 3:333-336....
Randall G. Mielke
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Since the unedited 5-HT2C-INI is more efficiently coupled to G proteins than the other isoforms, its increased expression in schizophrenia may lead to enhanced 5-HT2CR-mediated effects. The results also illustrate that potentially important receptor alterations may occur in schizophrenia which are ...
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