TP2, as purified from rat elongating spermatids, is shown here to contain 0.2 atoms of zinc bound per molecule of the protein by atomic absorption spectroscopy. On incubation with 10 渭M ZnCl2, invitro, and subsequent exhaustive dialysis, TP2 had 2 atoms of zinc bound per molecule. The ...
The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome. Cell Metab. 23, 610–621 (2016). Article CAS PubMed PubMed Central Google Scholar Rohrig, F. & Schulze, A. The multifaceted roles of fatty acid synthesis in cancer...
Such patients may not benefit from a single antagonist, but rather from combined simultaneous inhibition of two or three pathways. It is worth noting that small molecule inhibitors targeting members of GLI1 and mTOR pathway are currently being developed [46,47,48], and are increasingly being ...
The asymmetric units of (I) and (II) contain half of the tetrameric unit and additionally one molecule of toluene for (II). The ZnII atoms are four- and six-coordinated in distorted tetrahedral and octahedral geometries for (I), and six-coordinated in a distorted octahedral environment for...
IN WHAT IS BEING CALLED “A landmark discovery in the chemistry of zinc," researchers in Spain have prepared and characterized the first stable molecular compound containing a zinc-zinc bond { Science , 305 , 1136 (2004)}. The discovery was unexpected, says Ernesto Carmona, a professor of ...
zinc, making detection by mass spectrometry of BMAA in its native form (m/z119 in positive ionization mode) difficult (Nunn et al.1989; Glover et al.2012). Derivatization of BMAA can prevent the spontaneous formation of metal adducts during analysis since the amine groups of the molecule are...
Presumably, they provide a flexible linker to the remainder of the molecule, i.e., an acidic region followed by an array of eight C2H2 zinc fingers in the case of Grauzone (Chen et al., 2000). The arrangement of the different ZAD structural elements is summarized in Figures 2A–2C and...
Many studies from independent laboratories have implicated erythrocyte NO generation and/or delivery as a critical source of hypoxic vasodilation, although questions remain about the nature and stability of the molecule carrying “NO bioactivity”5,6,7,8. Other sources of NO for hypoxia-driven ...
The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients. 展开 关键词: MORC zinc finger lymphoma SEREX ...
A water molecule and Glu-319 serve as bridging ligands to the two metals with full occupancy. One of these metal ions is additionally coordinated by Glu-253 and His-348 and the other by His-381 and Asp-383. In addition, the metals are involved in weak metal-donor interactions to a ...