TP2, as purified from rat elongating spermatids, is shown here to contain 0.2 atoms of zinc bound per molecule of the protein by atomic absorption spectroscopy. On incubation with 10 渭M ZnCl2, invitro, and subsequent exhaustive dialysis, TP2 had 2 atoms of zinc bound per molecule. The ...
The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients. 展开 关键词: MORC zinc finger lymphoma SEREX ...
3a-c). This suggested that affinity between a single ISG15 molecule and RNF213 is too weak to detect, similar to a ubiquitin or SUMO molecule to their respective binding proteins51,52. Hence, we applied a Glutathione-S-Transferase (GST) pull-down assay in which we coated glutathione beads...
(Fig. 5d), while the F2b molecule is the main product from 3-J2 (Fig. 5e), in a RadA dose-dependent manner. Thus, RadA preferentially unwinds the 5′ ssDNA arm of both 3-J substrates. The level of unwinding of the 3-J substrates in the ‘3′ direction’ (named considering the ...
The N-terminal truncation of the first amino acid residue (H) does not result in a significant change in the conformation, zinc-binding capacity, thermodynamic stability, or biological activity, while truncations of the first three amino acid residues (FISH) or the first four amino acid ...
PIXE analyses of hamster protamines extracted under conditions that appear to at least partially preserve zinc binding also confirm that the majority of the metal is bound to protamine. In five of the species examined, sufficient zinc is present for each protamine 2 molecule to bind one zinc. ...
BACKGROUND AND AIM: Beta-catenin, as a major effector molecule in the canonical Wnt signaling pathway, could regulate adult neurogenesis. Here, the role of Wnt/β-catenin signaling pathway in the proliferation of hippocampal neural stem cells (NSCs) induced by hypoxia was investigated. METHODS: ...
1997). β-Glycosyltransferases can be categorized into processive or non-processive glycosyltransferases depending on the transfer of multiple or single sugar residue to an acceptor molecule. Processive glycosyltransferase is composed of two conserved domains (domains A and B), while non-processive ...
By contrast, one trial167 investigated the effect of micronutrients (including zinc) with or without heat-inactivated L. acidophilus compared with a placebo in infants aged 6–12 months at high risk of diarrhoea-related mortality (defined as at least one episode of diarrhoea in the preceding 2 ...
摘要: Publication » ISPERSE: A Novel Inhaled Dry Powder Delivery Platform For The Delivery Of Large Molecule Drugs To The Lung For Local And Systemic Treatments.DOI: 10.1164/ajrccm-conference.2012.185.1_MeetingAbstracts.A2761 年份: 2012 ...