In these chicks, intramuscular administration of xylazine (0.3–4.8 mg/kg) induced a loss of the righting reflex, the duration of which was dose-dependent. Both α-adrenoceptor antagonists of the α2 type, i.e. yohimbine (0.1–1.0 mg/kg) and compound 170150 (0.1–1.0 mg/kg) (a benzo...
In these chicks, intramuscular administration of xylazine (0.3–4.8 mg/kg) induced a loss of the righting reflex, the duration of which was dose-dependent. Both α-adrenoceptor antagonists of the α2 type, i.e. yohimbine (0.1–1.0 mg/kg) and compound 170150 (0.1–1.0 mg/kg) (a benzo...
Animals were anaesthetized using a cocktail of ketamine (75 mgÁkgÀ1, Ketaset, Zoetis, UK) and xylazine (3.75 mgÁkgÀ1, Rompun, Bayer, Germany) and 5 mlÁkgÀ1 of 0.5% Evans Blue (Alfa Aesar, Heysham, UK) injected intravenously, and the dorsal skin was shaved. Following ...
Control and conditional KO mice (postnatal days 14–20) were anesthetized with ketamine/xylazine and surgically implanted with a set of electrodes; two 0.1-mm-diameter silver wires were bonded; one was a 1.2-mm-long reference electrode, and the other was a 2.0-mm-long working electrode with ...
Xylazine did not reduce the release of ATP. Oxymetazoline, a relatively selective α2-adrenoceptor agonist failed to inhibit the release of [3H]noradrenaline. On the other hand, it enhanced the evoked release of ATP and potentiated both phases of contraction at concentrations of 0.1 and 1 μM....