noun Slang. a person who is tough, practical, and unsentimental, especially in business: We need a hard-nose to run the department.
Mutation of the cysteine located in HA2 that participates in this disulfide bond has been employed in crystallographic studies of HA2 to generate well behaved recombinant protein (24). Like IAV and IBV HA, the ISAV F protein is cleaved into two subunits during viral maturation by host proteases...