2). Moreover, Firefly NGS has successfully profiled three special mutations that were not included in the design of ddPCR (filled in blue, Supplementary Table 2), assisting the previously reported disadvantage of ddPCR for the requirement of detailed prior information on the mutational spectrum.23...
in response to uterine disease status. The rank of highly abundant discriminatory bacteria was almost the same regardless of health status, and the relative abundance of these taxa at both sites was more variable in the endometritis group than in the healthy group (Fig.2eand Supplementary Fig.4a...
CTC: Complex trait consortium QTL: Quantitative trait loci TAU: Tel Aviv University Kp: Klebsiella pneumonaie Kprl: Klebsiella pneumonia resistant locus CIs: confidence intervals SNP: single nucleotide polymorphic WTCHG: Wellcome Trsust Center for Human Genetics UNC: University of North Car...
The arbuscular mycorrhizal (AM) symbiosis consists of a mutualistic relationship between soil fungi and roots of most plant species. This association provides the arbuscular mycorrhizal fungus with sugars while the fungus improves the uptake of water and
As the 1.6 kb AaxmCesA1 probe included the HVRII region in its design, sequence variation might cause failure of the probe to hybridize and detect all the different isoforms. This also reflects the possible high sequence variation in the HVRII region of the AaxmCesA genes of the Acacia ...
following parameters: a mass tolerance of 20 ppm for precursor masses; 30 ppm for MS/MS, cysteine carbamidomethylation as a fixed modification and acetylation of the N terminus of the protein, pyroglutamate formation from N terminal glutamine, and oxidation of methionine as variable ...
Variable modifications allowed included protein N-terminal acetylation, methionine oxidation, pyro-glutamic acid for N-terminal glutamines, propionamide on cysteines, deamidation of glutamines and asparagines as well as phosphorylation of serines, threonines and tyrosines. Mascot results were imported ...
Plasminogen activator inhibitor 1 (PAI-1) overexpression is an important prognostic and predictive biomarker in human breast cancer. SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may play a role in gynaecological cancers as well, since upregulation of SERBP1 was ...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) post-transcriptionally degrades the low density lipoprotein receptors (LDLR). However, it is unknown whether PCSK9 acts directly on the LDLR or if PCSK9 activates another protein that in turn causes d
1996) were used to study historical recombinants on the disease chromosomes in the 29 affected homozygotes. Three kindreds included the most informative recombinants: kindreds A and H each included affected individuals heterozygous at D17S1787 but not at D17S1793, placing the gene distal or ...