, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, juvenile myoclonic epilepsy, and the seizures associated with Lennox-Gastaut syndrome. It is also used in treatment of myoclonus. In some countries, parenteral preparations of valproate...
Antitumor activity of sodium valproate in cultures of human neuroblastoma cells Valproic acid (VPA) is a simple branched-chain fatty acid that has anticonvulsant activity and is widely used in the treatment of epilepsy. VPA was found t... J Cinatl,J Cinatl,M Scholz,... - 《Anticancer Drugs...
Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model. J Neurosci 27: 5535–5545. Saha RN, Ghosh A, Palencia CA, Fung YK, Dudek SM, Pahan K (2009). TNF-alpha ...
To determine the effectiveness of six antiseizure medications (valproic acid, VPA; carbamazepine, CBZ; lamotrigine, LTG; perampanel, PER; brivaracetam, BRV; and everolimus, EVL), continuous 24-hour electroencephalography (EEG) was used in freely moving mice with intrahippocampal kainate-induced ...
Valproic acid (sodium salt; Sigma Chemical Co.) and lithium chloride (Sigma) were prepared in sterile water as concentrated stocks and added to the final concentrations as indicated in the figures. Valpromide (kind gift of Katwijk Chemie B.V.) was prepared in Me2SO. 2-Methyl-2-propyl...
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However, they found that treatment of cells with valproic acid, a pan-HDAC inhibitor, reduced oncolytic adenovirus activity and was associated with an increase in p21 expression. Recent evidence suggests that the number of genes responsive to valproic acid is at least 100 and may exceed 1000 [...
De Sarno P, Li X, Jope RS: Regulation of Akt and glycogen synthase kinase-3b phosphorylation by sodium valproate and lithium. Neuropharmacology. 2002, 43: 1158-1164. 10.1016/S0028-3908(02)00215-0. Article CAS PubMed Google Scholar Liljebris C, Baraczewski P, Björkstrand E, Byström...
Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium. Neuropharmacology 43: 1158–1164. Dencker D, Dias R, Pedersen ML, Husum H (2008). Effect of the new antiepileptic drug retigabine in a rodent model of mania. Epilepsy Behav 12: 49–53. ...
Valproic acid elevates Sox5 expression and insulin secretion. On the basis of the present findings, we postulate that the 168 open chromatin genes represent a core set of highly connected genes in the T2D-associated module that are suppressed in T2D, resulting in loss of secretory function. We...