(1983). Islet amyloid in type-2 (non-insulin-dependent) diabetes is related to insulin. Diabetologia 24:342–346.Westermark P, Wilander E (1983) Islet amyloid in type 2 (non-insulin-dependent) diabetes is related to insulin. Diabetologia 24: 342–346...
Amyloid deposition is the most typical islet alteration in Type 2 (non-insulin-dependent) diabetes. In the present study we show by immunohistochemistry that the amyloid reacts with an antiserum against insulin B chain. Islet amyloid was also purified, dissolved in guanidine-HCl and gel filtered ...
To study whether insulin resistance in Type 2 (non-insulin-dependent) diabetes mellitus is due to a defect in the expression of the insulin-responsive glucose transporter gene (GLUT-4) in human skeletal muscle, we measured the level of GLUT-4 mRNA and (in some of the subjects) its protein...
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for...
Consequently, HFD/STZ-treated mice with hepatic NGBR overexpression had increased insulin sensitivity and reduced beta-cell loss. Mechanistically, NGBR overexpression restored insulin signaling of AMPKα1-dependent phosphorylation of AKT and GSK3β. NGBR overexpression also reduced expression of ...
Intracellular eccDNA SORBS1circle expression was significantly enhanced in the high glucose and palmitate (HG/PA)-induced hepatocyte (HepG2 cell) insulin resistance model. Moreover, the upregulation of eccDNA SORBS1circle in the HG/PA-treated HepG2 cells was dependent on generation of apoptotic ...
111.Tajabadi- Ebrahimi, M. et al. A randomized controlled clinical trial investigating the effect of symbiotic administration on markers of insulin metabolism and lipid profiles in overweight type 2 diabetic patients with coronary heart disease...
Tubulointerstitial lesions in non-insulin dependent diabetes mellitus. Kidney Int. Suppl. 63, S191–S194 (1997). CAS PubMed Google Scholar Shimizu, M. et al. Long-term outcomes of Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy. Diabetes Care. 36(11), 3655–3662 ...
The odds ratio for developing diabetes while taking glucocorticoid therapy is in the range 1.3–2.328 and is dose-dependent. Hyperglycaemia in the post-prandial period is more severe and is related to a reduction in insulin sensitivity.29 There has been much debate about whether the higher ...
et al. A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. Nat Cell Biol 25, 565–578 (2023). https://doi.org/10.1038/s41556-023-01103-1 Download citation Received11 May 2022 Accepted02 February 2023 Published16 March 2023 Issue Date...