Lutein has been shown to potentiate the effect of taxane chemotherapy drugs Taxol (paclitaxel) and Taxotere (docetaxel) in breast cancer cells.Beta-carotene enhanced the cytotoxicity of Adriamycin in hormone receptor positive (ER+/PR+) and triple negative (ER-/PR-/HER2-) breast cancer cells in...
Luteolin has also been found to suppress triple negative breast cancer cell proliferation and metastasis and to reduce ER+/PR+ cell viability in a dose- and time-dependent manner. In addition, luteolin has been found to inhibit the growth, proliferation and migration of HER2+ breast cancer ...
“In general, it’s used more commonly forearly-stage cancer—stage 1, sometimes stage 2. Most of the time we’re giving it for estrogen-positive breast cancers,” saysHeide A. Rodgers, M.D.,a medical oncologist for Mercy Health System in St. Louis. Estrogen receptor-positive, or ER+...
Is Triple Negative Breast Cancer An Indian Problem - A Prospective Analysis From A Tertiary Care Oncology CentreParyani, JeetendarChaturvedi, ArunKumar, VijayJournal of Cancer Research & Therapeutics
Additionally, in the context of cancer, cancer-associated fibroblasts can express PD-L2 and contribute to an immunosuppressive tumor microenvironment10,11. PD-L2 expression is detectable in a large variety of human cancers, being most prominent in triple-negative breast cancer, and head and neck ...
growth through competitive binding of ERα [71]. AURKA promotes distant metastases in ERα-positive breast cancer cells [33,72] and its overexpression is strongly linked to decreased survival, high nuclear grade, and elevated HER-2/neu and progesterone receptor levels in breast cancer [73,74]....
Collectively, these data suggest that β-catenin is required for triple-negative breast cancer development by controlling numerous tumor-associated properties, such as migration, stemness, anchorage-independent growth and chemosensitivity. 展开 关键词: TRIPLE-negative breast cancer CATENINS ONCOGENIC viruses...
Variants from 19p13.1 were not associated with breast cancer overall or with ER-positive breast cancer but were significantly associated with ER-negative breast cancer risk [rs8170 OR, 1.10; 95% confidence interval (CI), 1.05-1.15; P = 3.49 x 10-5] and triple-negative (ER-, PR-, and H...
Both white and black mustard seeds are excellent sources of melatonin. Melatonin protects against ER+ breast cancer by reducingaromatase activitywithin the breast, thereby decreasing estrogen production. Melatonin has also been found to reduce triple negative (ER-/PR-/HER2-) breast cancer growth, pro...
Lutein consumption and circulating lutein levels have been found to be associated with reduced risk of breast cancer in several epidemiological studies. Lutein has been shown to inhibit the progression of both ER+/PR+ and triple negative breast cancer cells under hypoxia, a low-oxygen condition in...