Trazodone Vilazodone (Viibryd) Vortioxetine (Trintellix) Atypical Antipsychotics Some drugs that were first used to treat schizophrenia, called atypical antipsychotics, may also help certain kinds of depression, either alone or in combination with more traditional antidepressants. ...
Trazodone works by stimulating serotonin in the brain, but it's not a selective serotonin reuptake inhibitor (SSRI) like other well-known antidepressants such as fluoxetine (Prozac). The drug was originally approved by the FDA in 1981 to treat depression, but because it causes drowsiness, it'...