Background Tocilizumab (TCZ), an interleukin-6 receptor blocker, and anti-tumor necrosis factor (TNF) biologic agents are key therapies in the management of rheumatoid arthritis (RA). They are considered to be equally effective and very few head-to-head comparisons have been published. ...
Intravenous Tocilizumab: A Review of Its Use in Adults with Rheumatoid Arthritis biologic DMARDs, current evidence indicates that tocilizumab is effective as a first- or subsequent-line biologic in patients with moderate to severe RA.doi... Dhillon,Sohita - 《Biodrugs》 被引量: 32发表: 2014年...
Pharmacokinetics and tolerability of prefilled syringe and auto-injector presentations of MSB11456: results of a randomized, single-dose study in healthy a... Plain Language SummaryTocilizumab is a biologic drug that is used to treat autoimmune diseases, including rheumatoid arthritis. MSB11456 has be...
Tocilizumab: an interleukin-6 receptor inhibitor for the treatment of rheumatoid arthritis. To review the pharmacology, pharmacokinetics, clinical trial data, and safety profile of tocilizumab, a new biologic agent targeting the interleukin-6 cyto... Susyn,L,Plushner - 《Annals of Pharmacotherapy》 ...
Biologic drugs such as abatacept, adalimumab (Humira), certolizumab (Cimzia), etanercept (Enbrel), enercept-szzs (Ereizi), golimumab (Simponi, Simponi Aria), infliximab (Remicade), rituximab (Rituxin), and tocilizumab (Actemra). Some of these medications are traditionally used to treat other co...
Tocilizumab monotherapy is better than methotrexate monotherapy, with rapid improvement in RA signs and symptoms, and a favourable benefit鈥搑isk, in patients... G Jones,A Sebba,J Gu,... - 《Annals of the Rheumatic Diseases》 被引量: 1186发表: 2010年 Biologic and oral disease-modifying anti...
The syndrome is rooted in massive aberrant B-, T-cell and monocyte activation and a systemic “cytokine storm”. The clinical course is pleiotropic, with fever, skin rash, cytopenia, neurologic symptoms, coagulopathy, hypotension and eventually organ failure i.e. ARDS. Application of tocilizumab ...
Actemra (tocilizumab) This biologic drug inhibits the binding of inflammatory proteins known as cytokines to immune cells that prevent the immune cells from becoming activated, lowering inflammation levels. Actemra can be used as a single agent or in combination with other DMARDs. It takes about an...
tocilizumab, is used as an immunosuppressive drug in RA patients.30 TNF-α can bind to two specific receptors, TNFR1 and TNFR2, which are both expressed in RA synovium31 and OA cartilage.32 Here, we show that HIF-2α upregulates TNFR2 (encoded by Tnfrsf1b) in FLS but not chondrocytes...
Objective: Tocilizumab (TCZ) has potent therapeutic effects in the treatment of rheumatoid arthritis (RA), but the factors for predicting these effects are not clear. We compared patients refractory to disease-modifying antirheumatic drugs (DMARDs) (biologic agent na?ve: N group) and patients who...