Moreover, the oxygen-sensitive HIF1α-AS1 is down-regulated in pulmonary hypertension and loss-of-function approaches not only result in gene de-repression but also enhance angiogenic capacity. As exemplified here with HIF1α-AS1, DNA:DNA:RNA triplex formation is a functionally important mechanism...
Is it prime time for proactive therapeutic drug monitoring of anti-TNF therapy in IBD?doi:10.1053/j.gastro.2019.08.001Papamichael KCheifetz ASGastroenterology
U Nachbur1, H Anderton1, DL Vaux1 and J Silke*,1 On TNF binding, receptor-interacting protein kinase 1 (RIPK1) is recruited to the cytoplasmic domain of TNFR1, at which it becomes ubiquitylated and serves as a platform for recruitment and activation of NEMO/IKK1/IKK2 and TAK1/TAB2...
In a recent study, we identified an immunosuppressive function for DAT, where blockade of DAT activity enhanced LPS-mediated production of IL-6, TNF-α, and mitochondrial superoxide levels, demonstrating that DAT activity regulates macrophage immune responses. In the current study, we tested the ...
A prime example of this strategy is our recent Call for Papers: Diabetes Care Symposium (http://care.diabetesjournals. org/site/misc/CareCallforPapersAd.pdf), which is a way to solicit high-impact manuscript submissions for an annual symposium centered on diabetes care to be held in ...
3F). Induction of apoptosis is critically linked to elevated levels of TNF and NOS2 activity; thus, we further investigated the role of ArgD in the regulation of programmed cell death. We used FACS analysis to determine the effect of ArgD on induction of apoptosis. Our result revealed that ...
South Africa is a prime example of a water-stressed country fighting to keep water crises at bay. The nation faces the potential drying impacts of climate change coupled with a growing population putting increasing demand on water resources, while also carrying a historical legacy of inequitable wa...
Increased expression of pro-inflammatory cytokines (IL1,IL6,IL18), genes involved in cytokine-cytokine signaling cascades (IL1R,IL6R,TNFAIP3,TNFAIP6,TNFSF13B,PTX3), cell-cell adhesion (CDH1,ICAM1,FN1, ITGA2), tissue remodeling (VEGF), extracellular matrix (ECM), and proteolysis (SERPINE...
RACK1 was identified as a novel negative regulator of NF-κB signaling physically associated with the IKK complex in a TNF-triggered manner in 293 T cells13. This interaction interferes with the recruitment of the IKK complex to TRAF2, which is a critical step for IKK phosphorylation and su...
Thus, it is not surprising that these cells are the most preferred site of crystallization in the kidney72 and that they respond with the release of cytokines (e.g., MCP1, TNFα, or TGF-β) during prolonged episodes of cellular stress73,74. Our GO biological pathways suggested the ...