Is there any treatment for inflammatory amyloidosis?doi:10.1016/j.jbspin.2010.09.001Béatrice BouvardCédric AnnweilerAgnès SalléOlivier BeauchetDaniel ChappardMaurice AudranErick LegrandRetour au numéro
“EchoGo® Amyloidosis is going to be revolutionary, based upon the volume of undiagnosed patients that are out there. It’s going to undoubtedly detect patients and impact morbidity and mortality for this disease.” Faizi A. Jamal, MD, FACC , Chief, Division of Cardiology Director, Non-Inv...
Studying females in mouse models of AD: Human-relevant strategies Reproductive Aging Effects Hormone Therapy Effects Gnx vs Intact Gnx: Vehicle vs Hormone treatment Gnx vs E2 dominant* estrous stages Gnx vs P4 dominant** estrous stages Figure 4 Research strategy for studying females in mouse models...
Treatment for secondary renal amyloidosis may include medicines to decrease inflammation, such as: Biologic agents, like tumor necrosis factor (TNF) blockers Corticosteroids Monoclonal antibodies Dietary supplements such as fish oil Other treatments may include: ...
(acoramidis), an orally administered treatment for cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM). ATTRUBY is a near-complete (≥90%) stabilizer of transthyretin for the treatment of ad...
Isatuximab may be utilized in the treatment of AL amyloidosis. Preliminary findings of a phase 2 trial of intravenous isatuximab in 35 relapsed/refractory AL amyloidosis patients (who received one or more previous lines of therapy) has reported overall hematologic response rate at 77 %. 32 pati...
In 2021, a significantCRISPR trial for transthyretin amyloidosis, a neurodegenerative disease, showed very promising results. It is also revolutionizing pediatric cancer treatment, described inthis podcast interview with Shondra Miller from St Jude’s. ...
There is substantial evidence that anti-IL-1 agents have a strong steroid-sparing effect and considerable evidence that the use of disease-modifying anti-rheumatic drugs can also be reduced or stopped. Thus, the use of anti-IL-1 agents may reduce the side-effects of co-treatment. The high ...
There are parallels between amyloidosis and the assembly of immune cell signalling complexes. We speculate that the modification of ASC that we have identified may function as has been identified for the Mitochondrial antiviral signalling (MAVS) protein. In this instance, viral infection induces the ...
Diabetic patients were not included in the study to exclude the possible effects of exogenous insulin and insulin resistance on treatment. Blood samples were collected in the morning after at least eight hours of fasting for glucose, insulin, high density lipoprotein (HDL), triglycerides, and ...