lactis as an interesting alternative to ADI-PEG20 for future development. Our results show that the L. lactis Lc4 strain has a unique ability to release ADI to the supernatant, in stress-simulating conditions, as compared to Lc2 and Lc3 strains. The ADI pathway in bacteria consists of three...
There is an urgent need to evaluate the specific contribution of existing global climate finance. Besides, it is still challenging to fit China’s existing route into the global climate finance governance system so far. How to make up the huge discrepancy between the two systems can be a ...
1F, G), indicating an elevated anxiety level due to AMPK deficiency. However, there was no observed difference in locomotor activity between the AMPK KO and AMPK Flox mice (Supplementary Fig. 1G). Furthermore, testing of blood glucose levels in adult AMPK KO mice revealed no significant ...
86. As shown in Fig.4, there was no indication for the absence of evidential value because both tests for flatness were not significant (pFull = 0.47,pHalf = 1). However, thep-curve neither supported the presence of an evidential value because only one test for right-skewness wa...
Next-generation inhibitors (e.g., selitrectinib, repotrectinib) maintain activity against these TRK mutant tumors; however, there are no next-generation TRK inhibitors approved by the FDA and select trials have stopped treating patients. Thus, the identification of novel, potent and specific ...
Huang TH,Shui HA,Ka SM,et al.Rab 23 is expressed in the glome-rulus and plays a role in the development of focal segmental glomeru-losclerosis. Nephrology Dialysis Transplantation . 2009Huang, T.H. , Shui, H.A. , Ka, S.M. , Tang, B.L. , Chao, T.K. , Chen, J.S. , ...
3.1. Genetic lesion of YFT1 in yft1 causes a yellow-fruited phenotype due to an insertion of 573 bp DNA The yellow-fruited phenotype of yft1 was previously inferred to be due to a genetic lesion in a homolog of EIN2 (Solyc09g007870) [31], but there still is lack of genetic eviden...
In mammals, the VPS23A homolog Tsg101 possesses a UEV domain that resembles the UBC domain of E2 ubiquitin conjugase but lacks an active cysteine residue known to be essential for the catalytic activity of E2 enzymes (Hochstrasser, 2000). The observation that the UEV domains can still bind ub...
2j), suggesting an active metabolic flow from glutamate to α-KG feeding into the TCA cycle in TNBC cells. Consistently, there was a significant decrease in the molar ratios of isocitrate/α-KG and citrate/α-KG in the IDH2-knockdown cells (Fig. 2k)....
The tripartite motif-containing protein 21 (TRIM21) plays important roles in autophagy and innate immunity. Here, we found that HECT and RLD domain containing E3 ubiquitin protein ligase 5 (HERC5), as an interferon-stimulated gene 15 (ISG15) E3 ligase, c