An effective vaccine or therapeutic agent for treating DENV infection is unavailable to date. Therefore, there is a high need to identify a potential viral or host target for developing an anti-DENV drug. DENV is an enveloped, positive-stranded RNA virus belonging to the family Flaviviridae3. ...
Because vaccine viruses are grown in animals or in cells derived from them, there is always a possibility that a vaccine will be contaminated with another virus from that animal or from the medium used for culturing its cells. An early example, which led to restrictions on international trade ...
van Orischot et al., "6.2 Construction of a recombinant vector vaccine against bovine herpes virus (BHV) type 1 and bovine respiratory syncytial virus (BRSV) infections", pp. 122-127 (1990). Primary Examiner: SALIMI, ALI REZA Attorney, Agent or Firm: ...
For co-localisation analysis, DEFs were plated onto glass slides in 12-well plates. The following transfections or infections were conducted: (1) DEFs were co-transfected with 500 ng of various plasmids pCAGGS-gI-Flag, pCAGGS-gIN69A-Flag, pCAGGS-gIN78A-Flag, pCAGGS-gIN265A-Flag, pCAGGS-gIN...
s significant role in viral pathogenicity, it has become a potential target for studying the mechanisms of viral attenuation [13,14]. However, the molecular mechanisms by which gI is involved in DPV attenuation have not yet been reported. This indicates that there is still a knowledge gap in...
As of now, there is no effective vaccine against either HSV-1 or HSV-2 [4,5]. More importantly, there seems to be a lack of mechanistic understanding of the effect of immune response elicited by infected epithelial cells on the spread of infection to the nervous system [6]. In α-HV...
Due to its ability to cause widespread infection, BoHV-1 has a persistent negative economic impact on the cattle industry [14,15]. Essential to creating an effective vaccine are the understanding of viral mechanisms necessary for productive infection and immune stimulation, and identification of ...
Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus, belonging to Rhadinovirus genus, with no clear association with disease. However, there is increasing evidence of its secondary pathogenic role in cases of post-partum metritis in cattle. BoHV-4 Open Reading Frame 8 (ORF8) codifies for ...
An effective vaccine or therapeutic agent for treating DENV infection is unavailable to date. Therefore, there is a high need to identify a potential viral or host target for developing an anti-DENV drug. DENV is an enveloped, positive-stranded RNA virus belonging to the family Flaviviridae3. ...
Loss of the common "A" determinant of hepatitis B surface antigen by a vaccine-induced escape mutant. J. Clin. Investig. 1992, 90, 2543–2547. [CrossRef] [PubMed] 39. Raimondo, G.; Caccamo, G.; Filomia, R.; Pollicino, T. Occult HBV infection. Semin. Immunopathol. 2013, 35, 39...