There were no known kidney diseases in the family. A genomic sequence analysis of the COL4A3 and COL4A4 genes in both patients revealed a homozygous muta- tion (c.4523-1G > A) in intron 46 of the COL4A4 gene, which resided in the AG consensus splice acceptor. The case ...
Moreover, combining the two drugs did not give superior results to ramipril monotherapy, and there were more adverse events (i.e., hypotension and renal dysfunction). These findings indicate that telmisartan should be the preferred alternative to ramipril as the treatment of choice for patients ...