The abscopal effect refers to the ability of localized radiation to trigger systemic antitumor effects. Over the past 50 years, reports on the abs
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the effect of adjuvants on increasing the breadth of cross-reactivity is less well understood. In this study we have performed a systematic screen of different toll-like receptor (TLR) agonists, with and without a squalene-in-water emulsion on the immunogenicity of a recombinant...
Different generations of CARs have been developed by modifying different parts of the CD3z chain, including the extracellular antigen-binding domain (usually the single chain variable fragment of an antibody), transmembrane domain, and intracellular signaling domain, in addition to modifying costimulator...
Presents a study to determine the physiological function of inducible co-stimulator (ICOS) with homology to CD28 by generating and characterizing gene-targeted ICOS-deficient mice. Confirmation of germline transmission of the ICOS mutation by Southern blotting; Analysis of activated T-cells; Evidence ...
For the potential treatment of cancer and infectious diseases, the development of stimulator of interferon genes (STING) agonists has been a significant step. The crystal structure of SR-717 bound to hSTING served as the blueprint for the design and synthesis of a novel class of bipyridazine ...
IFN-β promoter stimulator 1 localizes to the mitochondrial membrane where it is activated by RIG-I/MDA5 through caspase recruitment domain (CARD)-CARD interactions (20). Although TLR- and RIG-I/MDA5-mediated signaling is transmitted via interaction of unique domain structures, TIR and CARD, ...
Correlating with the lack of effective immunity, the high in vitro CD4 þ /CD8 þ /NK cell infection rates (10.4–26.8%) persisted for those who succumbed (Fig. 3i–k), while the infection rate fall for CD8 þ T cells (d18 for R1, d14 and d22 for R2 and d22 and d30 for...
the main structural component of the flagellum, is an effective stimulator of innate immunity50and promotes mucosal immunity through the activation of TLR551. Another functional pathway that is potentially interacting with the human immune system early on is the resistance to cationic antimicrobial pepti...