Methodology used; Clinical definition of taxol and taxotere; Results and discovery.MoosPhilipJ.FitzPatrickF.A.EBSCO_AspProceedings of the National Academy of Sciences of the United States of AmericaTaxane-mediated gene induction is independent of microtubule stabilization: induction of transcription ...
Want to thank TFD for its existence?Tell a friend about us, add a link to this page, or visitthe webmaster's page for free fun content. Link to this page: Facebook Twitter Acronyms browser? ▲ SUAR SUARAM SUAREC SUARF SUAS SUAS-O ...
Lutein has been shown to inhibit the progression of both ER+/PR+ and triple negative breast cancer cells under hypoxia, a low-oxygen condition in which solid breast tumors can thrive. Lutein has also been shown to potentiate the effect of taxane chemotherapy drugs (Taxol and Taxotere) in ...
after neoadjuvant chemotherapy (NAC), and short-term response in a cohort of stage IIA-IIIC breast cancer patients (n = 84).All patients were treated with two to four preoperative cycles of FAC (5-fluorouracil-adriamycin-cyclophosphamide), CAX (cyclophosphamide-adriamycin-xeloda) or taxane regimes...
We studied the role of caspase-2 in apoptosis induction by taxanes (paclitaxel, novel taxane SB-T-1216) in breast cancer cells using SK-BR-3 (nonfunctional p53, functional caspase-3) and MCF-7 (functional p53, nonfunctional caspase-3) cell lines. Results Both taxanes induced apoptosis in ...
Docetaxel is an antineoplastic taxane that is widely used for the treatment and management of patients with breast1 and prostate cancers2. Docetaxel acts by disrupting microtubule disassembly, resulting in inhibition of mitosis, and ultimately leading to apoptosis2. However, drug-related cumulative toxic...
The following substances are considered to be effective and suitable for combination therapy: 5-FU +/- folic acid, cisplatin, irinotecan, etoposide, taxol, and taxotere. In contrast, the effect of doxorubicin and epidoxorubicin is only moderate. Although "second generation" combinations, such as ...
Find out about the science and chemistry of Docetaxel (Taxotere), see colourful images of Docetaxel and explore interactive 3D molecules of Docetaxel
Taxol/paclitaxel and its semisynthetic analog Docetaxel/Taxotere are also used as chemotherapeutic agents to treat a wide variety of solid tumors. Colchicine is not used for cancer treatment, probably due to high levels of toxicity, but other molecules targeting the colchicine-binding sites are under...
Docetaxel (Taxotere) /cyclophosphamide TCGA: The Cancer Genome Atlas TNBC: Triple negative breast cancer VUS: Variants of unknown significance Vecchi M, Confalonieri S, Nuciforo P, Vigano M, Capra M, Bianchi M, Nicosia D, Bianchi F, Galimberti V, Viale G. Breast cancer metastases are molecular...