aTamoxifen.—The uterus can exhibit prominent enlargement and severe zonal anatomy distortion with use of tamoxifen, which is widely used for breast cancer treatment (12). Tamoxifen. 子宫以它莫西芬的使用可以展览突出的放大和严肃带状的解剖学失真,为乳腺癌治疗是广泛使用的 (12)。 [translate] ...
KPNA1 regulates nuclear import of NCOR2 splice variant BQ323636.1 to confer tamoxifen resistance in breast cancer. Clin Transl Med. 2021;11(10):e554. https://doi.org/10.1002/ctm2.554. Article CAS PubMed PubMed Central Google Scholar Lan X, Zhao L, Zhang J, Shao Y, Qv Y, et al. ...
The interpretation, however, is not that those patients obtained benefit specifically from one or another cytotoxic drug; it simply allows concluding that the benefit from tamoxifen was insufficient and thus they were offered multiagent chemotherapy regimens without a rationale choice of one cytotoxic ...
Tamoxifen screws with my body temperature. Physically, I am hotter than I used to be and it’s not just during the hot flushes. This made winter a lot easier, but if we have a scorching summer I’m going to really suffer. It’s not so much that one hot day, but when they bank ...
with tamoxifen (1 mg/25 mg body weight) once daily for 5 days to induce knock out of the Ulk1 gene. All mice were housed in temperature-controlled (21 °C) quarters with 12:12-h light-dark cycle and ad libitum access to water and chow (Purina). We chose to study the FDB ...
Tamoxifen resistance remains a significant clinical challenge for the therapy of ER-positive breast cancer. It has been reported that the upregulation of transcription factor SOX9 in ER+ recurrent cancer is sufficient for tamoxifen resistance. However, t
DNA Adducts Formed from 4-Hydroxytamoxifen Are More Mutagenic than Those Formed by α-Acetoxytamoxifen in a Shuttle Vector Target Gene Replicated in Human ... It is not known if the induction of endometrial cancer in women is through these DNA adducts or through the estrogenic nature of the ...
a reduced sensitivity to the ER antagonists fulvestrant and tamoxifen [36,102]. Furthermore, the loss of ER expression has been observed in ER-positive breast cancer patients resistant to CDK4/6 inhibitors [102]. Together, the down-regulation of ERα expression and transcriptional activity might...
Upon induction with tamoxifen, the promoter activity is greatly reduced compared to untreated FRTL5-ERTM-Ras cells (Fig. 1H). These findings show that KLHL14 expression is lost in human undifferentiated thyroid cancer as well as in different experimental models of such tumors, similarly to what ...
Tamoxifen-inducible Ucp1-CreERT2 mice crossed with NuTRAP mice were used to assess active Ucp1 expression in adult mice. Immunostaining, RNA analysis, and single-cell/nucleus RNA-seq (sc/snRNA-seq) data analysis were performed to determine the expression of endogenous UCP1 and Ucp1-Cre-...