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IRF-1 or both. Data are presented as mean ± SD (***p < 0.001; ****p < 0.0001;##p < 0.01;###p < 0.001;n = 3).bChIP analysis was used to analyze IRF-1 occupancy at the AT2R promoter (**p < 0.01; ***p...
Single-gene image resolution back links genome topology, promoter-enhancer connection and transcribing management. Posted on February 19, 2025 The primary endpoint was patient survival to discharge, unburdened by substantial adverse health outcomes. Outcomes of ELGANs born to mothers with cHTN, HDP,...
(F) Chromatin interactions (3C) between the promoter and the super-enhancer’s regions at Dnmt3a and Bcl6 in Mll4f/f and Mll4 BSKO cerebella. (G) Chromatin interactions (3C) among the various regions in the super-enhancers at Dnmt3a and Bcl6 in Mll4f/f and Mll4 BSKO cerebella. ...
The gene for the proapoptotic transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein/growth arrest and DNA damage-inducible protein 153 (CHOP/GADD153) is induced by various cellular stresses. Previously, we described that inhibition of phosphatidylcholine (PC) synthesis in MT...
(ELISA) detecting the extracellular, N-terminal HA epitope of the wild-type FZD or mutated receptors. For six of the 32 predicted micro-switch mutants, expression levels fell below the detection limit of the method (Fig.1c, red labeling; Supplementary TableS2). Some of these were, however,...
(NC) into CHO-K1 cells, and luciferase activity was significantly suppressed by miR-144. Meanwhile, miR-144 had no effect on aSmad43′-UTR mutated dual-luciferase construct (Figure 2c). qRT-PCR and western blot analysis revealed that miR-144 significantly inhibited theSmad4mRNA level and ...
3 ERK regulates ES cell enhancer activity. a, RT–qPCR analysing the expression of eRNA at pluripotency super enhancers. Fgf4−/− ES cells were stimulated for either 30 or 90 min with 40 ng ml−1 recombinant FGF4 before analysis. *P < 0.05 and **P < 0.01, two-tailed Student’s...
(f) ChIP-seq density heatmaps show the enriched binding of Chd7 to super-enhancers (SEs) defined by H3K27ac. The start (S) and end (E) of SEs and ±5 kb surrounding the enhancer regions are shown. (g) IGV track view of ChIP-seq density profile for Chd7 and H3K27ac of Neuro...
(i.e., metastasize). As used herein, the term “cancer cell” is also intended to encompass those cells referred to as “pre-cancerous,” i.e., cells that contain mutated or damaged DNA or other components, which mutations or damage are likely to cause the cell to develop into a ...