The post-translational modification S-sulfenylation functions as a key sensor of oxidative stress. Yet the dynamics of sulfenic acid in proteins remains largely elusive due to its fleeting nature. Here we use single-molecule force-clamp spectroscopy and
a, Summary of the mammalian folate and methionine cycles (1C metabolism) and the transsulfuration pathway. Enzymes are marked in green. Coenzyme vitamin B12is marked in red. DHF, dihydrofolate; THF, tetrahydrofolate; MTs, methyltransferases; ACHY, adenosylhomocysteinase; CSE, cystathionine gamma-l...
Biogenesis of iron-sulfur proteins in eukaryotes: a novel task of mitochondria that is inherited from bacteria. Biochem. Biophys. Acta 1459, 370-382.Muhlenhoff U, Lill R (2000) Biogenesis of iron-sulfur proteins in eukaryotes: a novel task of mitochondria that is inherited from bacteria. ...
They are chemical compounds that are bound to proteins in the body. Without a cofactor attached, a protein cannot carry out its biological function. Cofactors are also known as helper molecules, and are often classified according to how tightly they are bonded to their protein partner. Tightly ...
(13 to 54 nmol/min/mg protein); the maximum activity of AChE was recorded in January, which could be interpreted as an indication of little or not exposure to OPs or carbamates at that time. The minimum AChE activity was found in April-May (Figure 4). Gills CbE activity showed a ...
N-Glycosylation is one of the predominant posttranslational modifications, which is found in all three domains of life. N-Glycosylation has been shown to influence many biological aspects of proteins, like protein folding, stability or activity. In this study we demonstrate that the archaellum filam...
Maturation of the latter proteins involves the ABC transporter Atm1p which presumably exports iron–sulfur clusters from the organelle. This review summarizes recent developments in our understanding of the biogenesis of iron–sulfur proteins both within bacteria and eukaryotes. 展开 关键词: Animals ...
Together, our results demonstrate that the cytosolic iron-sulfur cluster assembly scaffold is an ATPase and pave the way for interrogating the role of nucleotide hydrolysis in cluster biogenesis by this large family of cluster scaffolding proteins found across all domains of life. 展开 ...
found in previously described bacteria that perform dissimilatory perchlorate or chlorate reduction (clade 4). Many of the largest clades include Cld proteins with biochemically verified chlorite: O2lyase activity, and the key residues for activity were conserved in all clades except clade 38 (n =...
Thiosulfate oxidation by microbes has a major impact on global sulfur cycling. Here, we provide evidence that bacteria within various Roseobacter lineages are important for thiosulfate oxidation in marine biofilms. We isolate and sequence the genomes of