The mitochondrial DNA (mtDNA) depletion syndrome is a quantitative defect of mtDNA resulting from dysfunction of one of several nuclear-encoded factors responsible for maintenance of mitochondrial deoxyribonucleoside triphosphate (dNTP) pools or replication of mtDNA. Markedly decreased succinyl-CoA synthetase...
For example, nicotinamide adenine dinucleotide participates in the transformation of isocitrate into succinyl-CoA in the TCA cycle, and low [NAD +]/[NADH] ratio should result in a significant drop of the succinate and fumarate concentrations. However, in our measurements we did not observe any...
ATP is a crucial molecule for our metabolism. Not only does it provide us energy, ATP is responsible for an array of other vital functions, like transporting macromolecules in and out of the cell and through the cell membrane, and being an extracellular and intracellular signaling molecule (an ...
Benzoyl-CoA oxygenase leads to formation of 2,3-epoxide followed by enoyl-CoA hydratase (also expressed on KL) and NADP+-dependent aldehyde dehydrogenase (upregulated on KL)-mediated degradation resulting into formic acid, acetyl-CoA, and succinyl-CoA formation [29]. 1,2-phenylacetyl-CoA ...
Glutaryl-CoA is structurally similar to succinyl-CoA and malonyl-CoA (Figure 1A) and is an important metabolite of amino acid metabolism (Figure 1B and see Figure S1 available online). We predicted that glutaryl-CoA could serve as the donor molecule for the Kglu reaction (Koeppen et al., ...
Crucially important within the mitochondrial enzymatic landscape, 5'-aminolevulinate synthase (ALAS) catalyzes the initial step in heme production, forming 5'-aminolevulinate from glycine and succinyl-CoA. Indirect genetic effects We present here that MeV disruption of the mitochondrial network occurs ...
Which step of the cellular respiration process produces the most ATP per molecule of glucose? A) NADH is oxidized by the electron transport chain. B) FADH_2 is oxidized by the electron transport chain. C) Glucose is reduced to pyruvate....
Benzoyl-CoA oxygenase leads to formation of 2,3-epoxide followed by enoyl-CoA hydratase (also expressed on KL) and NADP+-dependent aldehyde dehydrogenase (upregulated on KL)-mediated degradation resulting into formic acid, acetyl-CoA, and succinyl-CoA formation [29]. 1,2-phenylacetyl-CoA ...
The AMP-forming acetyl-CoA synthetase is regulated by lysine acetylation both in bacteria and eukaryotes. However, the underlying mechanism is poorly understood. The Bacillus subtilis acetyltransferase AcuA and the AMP-forming acetyl-CoA synthetase AcsA
Křivánek, J. and Nováková, L., “The 34 kDa mitochondrial protein, phosphorylation of which is inhibited by vanadate, is the α-subunit of succinyl-CoA synthetase,” FEBS Letters, Vol. 254, pp. 121-123 (1989). :Křivanek, J. and Novakova, L., "The 34 kDa mitochondrial protein...