For example, if one community suspects that stem cells are stem cells as a result of their genetic activa- tion, the results derived from a research group pointing out the importance of stem cell population structure may be ignored, or simply reinterpreted in terms of genetic activation. But,...
Given the high degree of flexibility in stem cell states, it is plausible that as cells exit from a primed pluripotent state, hESCs would confront either differentiation into three germ layers or dedifferentiation toward a naïve-like state. The concept of embryonic dedifferentiation is supported ...
1f), as well as a number of additional proteins that are putative CARM1 substrates (Supplementary Data S1B). CARM1 is a transcriptional coactivator for NFIB NFIB is a transcription factor that governs the expression of numerous genes critical for SCLC differentiation, hair follicle stem cell ...
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As one side of the rocker arm moves up , the other side moves down , just like a seesaw . The downward-moving side of the rocker arm pushes on the valve stem to open the valve . Because a push-rod valve train has additional parts , it is more difficult to run at high speeds . ...
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Stem Cell Research & Therapy (2022) 13:358 https://doi.org/10.1186/s13287-022-03026-4 RESEARCH Open Access CD26 is a senescence marker associated with reduced immunopotency of human adipose tissue‑derived multipotent mesenchymal stromal cells Rose Triantafillia Psaroudis1, Urvashi...
Claudin18.2 (CLDN18.2) is a highly selective marker protein that is exclusively expressed in differentiated gastric mucosal membrane epithelial cells, has highly limited expression in normal healthy tissues and is not expressed in undifferentiated gastric stem cells [7]. In normal healthy tissue, CLDN...
In mouse embryonic stem cells (ESCs) and primary somatic tissues, such as liver and brain, H3K9me2-enriched chromatin domains (up to 5 Mb) have been identified (Wen et al., 2009). Within such domains, a negative correlation between H3K9me2 deposition and gene expression is observed (Wen ...
It is not known whether the germ line has any means of curbing mutations at PPRs, or whether the Z-DNA structure is controlled in germ cells. Here we show that Z-DNA is remodelled in the mammalian germ line. ZBTB43 is a member of the Broad-complex, Tramtrack and Bric-à-brac (...