Antiarrhythmic drug approaches dominated early attempts to prevent SCD; however, several trials with sotalol and amiodarone revealed an unacceptably high rate of recurrent arrhythmic events. With the advent of the implantable cardioverter defibrillator (ICD), the primary role of antiarrhythmic drug therapy...
Sotalol is a medication used to treat irregular heartbeat. Though effective, sotalol can cause life-threatening complications...
To stabilize Rica's heart rate, the doctor would probably administer an antiarrhythmic drug. An example of this would be beta-blockers, which reduce stress on certain parts of the body, such as the heart and the blood vessels in the brain. Such medication lowers blood pressure thereby ...
managed effectively with rate control alone, patients may take medications that correct the underlying rhythm problem. Examples include sotalol, amiodarone, and ibutilide. Long-term therapy has the potential to cause many side effects, so patients are screened carefully before startingantiarrhythmicdrugs...
Multicenter trial of sotalol for suppression of frequent, complex ventricular arrhythmias: A double-blind, randomized, placebo-controlled evaluation of two... Sotalol is a unique beta-adrenergic blocking agent with additional actions characteristic of Vaughn-Williams class III antiarrhythmic agents in exper...
Atrial fibrillation: antiarrhythmic medications such as flecainide, Betapace (sotalol), Pacerone (amiodarone), plus calcium-channel blockers9 Anxiety disorders such as PTSD or stage fright: antidepressant or anti-anxiety medications such as SSRIs like Zoloft (sertraline), Lexapro (escitalopram), SNRIs...
The K+ channel regulator KCR1 (38) protects heterologously expressed HERG current (IHERG) from block by the antiarrhythmic drugs dofetilide, quinidine, and sotalol over clinically relevant concentration ranges (16). Moreover, a polymorphism associated with a reduced risk for aLQTS was shown to ...
Ivabradine was clearly antiarrhythmic in our post-MI rats, reducing arrhythmic mortality, incidence and duration of ventricular arrhythmias as well as VPBs to a similar degree as an established therapy, metoprolol. Furthermore it did not prolong QT or MAP as might be expected had it inhibitedIK...
A multicentre, double-blind randomized crossover comparative study on the efficacy and safety of dofetilide vs sotalol in patients with inducible sustained... Antiarrhythmic drugs are still used for the treatment of ventricular tachyarrhythmias, in combination with implantable cardioverter-defibrillators ...
In the future, antiarrhythmic agents will continue to be used acutely to terminate a broad range of sustained arrhythmias. Chronic use is likely to depend on the development of safer and/or more effective compounds, as well as on improved ways of predicting which patients are likely to develop...