Assessment by beta-1 selectivity showed that hypotension and bradycardia were more frequent with non-selective beta-blockers (sotalol) than comparators (RR 4.57, 95% CI 1.92–10.85; p=0.001 and 5.97, 95% CI 1.34–26.57; p=0.019). CONCLUSION. There is no difference between IV beta-blockers...
In this context we have recently shown that ivabradine, a putative selective inhibitor of cardiac pacemaker F current (IF) flowing through hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and pure HR reducing agent that is devoid of hemodynamic effects of β-blockers4, reduces ventri...