The drug is effective because the Fe2+ present in infected erythrocytes acts non-enzymatically to convert ART to toxic products. We tested the effects of ART on drug-sensitive (H69) and multi-drug-resistant (H69VP) SCLC cells, pretreated with transferrin (TF) to increase the intracellular ...
The study's findings suggest that platycodin D (PD), a saponin constituent of Platycodon grandiflorum, impacted the proliferation, invasion, and migration of LoVo and OR-LoVo cells negatively. The combined treatment of LoVo and OR-LoVo cells with oxaliplatin and PD resulted in a dramatic decline...
The antibacterial activity of loquat leaves is weak, which is attributed to the fact that the saponin component contained in the raw material medicine is small. 4.2.4. Ya-Samarn-Phlae Ya-Samarn-Phlae (YaSP) is a traditional Thai multiherbal formula for the treatment of chronic wounds and...
Following exposure to butyrate and saponin, there was a dose-dependent increase in the numbers of neutrophils and macrophages within the larval gut.A synergistic omics and imaging methodology offered an integrated perspective on butyrate's impact on fish gut health, uncovering novel inflammatory-like ...
Drug-related toxic effects on the retina described in humans and animals are unrelated to melanin binding: melanin binding and retinal toxicity are two separate entities, the latter being related to the intrinsic toxicity of the compound rather than its ability to bind. Chloroquine and phenothiazines...
capitiformis showed the presence of alkaloid, saponin, terpennoids, steroid and flavonoids etc. with the % yield of crude 2.04%.With an IC50 of 45.35 µg/ml, the whole plant methanolic preparation has antioxidant activity equivalent to ascorbic acid. Anti-arthritic protein blocking dropped ...
Soluble protein lysate derived from saponin-liberated P. falciparum trophozoites was analyzed by mass spectrometry to identify internalized host RBC proteins. PRDX6 was one of 97 host RBC proteins that were detected with a high degree of confi- d...
While the elimination half-life of BPA is short in humans (<2 hr), but cadmium has a half-life of >20 years so that considerable amount of toxic level of cadmium can build up in humans over time. Thus, the observation that human Sertoli cells are susceptible to these toxicants is ...
Diosgenin, a steroidal saponin present in fenugreek, has been shown to suppress inflammation, inhibit proliferation, and induce apoptosis in various tumor cells. Research during the past decade has shown that diosgenin suppresses proliferation and induces apoptosis in a wide variety of cancer cells line...
Many saponin glycosides exhibit toxic effects at high doses over an extended period, causing problems such asexcessive salivation, diarrhea, vomiting, loss of appetite, and manifestations of paralysis (Table 8.5). What does saponins do to the body?