The formation of the nervous system requires a balance between proliferation, differentiation, and migration of neural progenitors (NPs). Mutations in genes regulating development impede neurogenesis and lead to neuropsychiatric diseases, including autis
It has been reported that miR-377-3p can exacerbate cerebral ischemia/reperfusion injury in MCAO/R rats [9]. Nevertheless, the specific mechanism of miR-377- 3p in regulating ischemic stroke remains unclear. Berberine (BBR) is a polycyclic compound found in the Coptis chinensis, and has been...
Expression of Paqr5b in olfactory mucosa (OM). (A) Expression analysis of Paqr5b in the OM. Proteins in the OM ofpaqr5b+/+andpaqr5b−/−zebrafish were detected by Coomassie Brilliant Blue R staining (CBBR). Paqr5b in the OM was detected with an anti-zebrafish Paqr5b antibody (...
cells Article Cannabigerol Is a Potential Therapeutic Agent in a Novel Combined Therapy for Glioblastoma Tamara T. Lah 1,2,3,*, Metka Novak 1, Milagros A. Pena Almidon 4, Oliviero Marinelli 4 , Barbara Žvar Baškovicˇ 1, Bernarda Majc 1,3, Mateja Mlinar 1, ...
The upstream causes of this are as yet unclear, but may include changes in genes controlling alternative splicing; a major regulator of gene expression which ensures genomic plasticity. Here, we provide evidence that treatment with novel analogues of the stilbene compound resveratrol is associated not...
K.M. Fox, R.C. Sterling, E.J. Van Bockstaele Cannabinoids and novelty investigation: influence of age and duration of exposure Behav. Brain Res., 196 (2) (2009), pp. 248-253, 10.1016/j.bbr.2008.09.033 View PDFView articleView in ScopusGoogle Scholar Frazer and Morilak, 2005 A. Fr...
Allada R, Cirelli C, Sehgal A.Molecular mechanisms of sleep homeostasis in flies and mammals.Cold Spring Harb Perspect Biol.2017;9(8):a027730. doi:10.1101/cshperspect.a027730 Nall AH, Shakhmantsir I, Cichewicz K, Birman S, Hirsh J, Sehgal A.Caffeine promotes wakefulness via dopamine signa...
Saglin, a 100 kDa protein composed of two 50 kDa homodimers, is present in the salivary glands of Anopheles gambiae and has been considered an essential receptor for sporozoites (SPZ) of Plasmodium berghei and Plasmodium falciparum (Pf), allowi
LIF, a key mediator of uterine receptivity, is expressed in glandular epithelial cells and regulated by epithelial ESR18, 13, 17. Loss of glandular LIF expression impairs receptivity13. As expected, Lif transcript was comparable in both Esr1f/− and Amhr2Cre/+; Esr1f/− uteri in the E...
We identify berberine (BBR), a compound isolated from a Chinese herb, as a new cholesterol-lowering drug. Oral administration of BBR in 32 hypercholesterolemic patients for 3 months reduced serum cholesterol by 29%, triglycerides by 35% and LDL-cholester