Takahashi A, Loo TM, Okada R, Kamachi F, Watanabe Y, Wakita M, Watanabe S, Kawamoto S, Miyata K, Barber GN, et al. Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells. Nat Commun. 2018;9:1249. Article PubMed PubMed Central Goo...
What Is a Daibutsu? The term 'Daibutsu' means the Great Buddha and is one of the icons of Japan. The Kamakura Daibutsu is a statue of the Buddha seated serenely in the grounds of Kotokuin, a Buddhist temple belonging to the Pure Land sect of Japanese Buddhism. Kamakura-Daibutsu is t...
Mounting evidence indicates that the lysosome-autophagy pathway plays a critical role in iron release from ferritin, the main iron storage cellular protein
Participants completed 12 sessions over a four-week period, either RT or END training in a ran- domised, balanced cross-over design (Fig. 1). Detraining adaptations (following either END or RT) seem to fol- low a similar time course to that of training adaptations in young, untrained ...
Image Credit: Dean Takahashi Chris Zimmerman:We’re trying to build a time machine here, a machine that takes you back to this place in time: Tsushima during the Mongol invasion in 1274. For me, this part of the demo is a particularly good time machine. If you go to ...
Takahiro KimuraDepartment of Urology The Jikei University Hospital Tokyo JapanShun SatoDepartment of Pathology The Jikei University Hospital Tokyo JapanHiroyuki TakahashiDepartment of Pathology The Jikei University Hospital Tokyo JapanMedical electron microscopy...
The replication of Ebola virus (EBOV) is dependent upon actin functionality, especially at cell entry through macropinocytosis and at release of virus from cells. Previously, major actin-regulatory factors involved in actin nucleation, such as Rac1 and A
Long-term ligand activation of PPARα in mice causes hepatocarcinogenesis through a mechanism that requires functional PPARα. However, hepatocarcinogenesis is diminished in both Ppara-null and PPARA-humanized mice, yet both lines develop age-related liver cancer independently of treatment with a PPARα...
Magnesium (Mg2+) is an essential nutrient in all organisms. However, high levels of Mg2+ in the environment are toxic to plants. In this study, we identified the vacuolar-type H+-pyrophosphatase, AVP1, as a critical enzyme for optimal plant growth under
Takahiro Yoneyama 1, Yasuhiro Hashimoto 2, Takuya Koie 1, Masakazu Tanaka 3, Shin-Ichiro Nishimura 3, Shizuka Kurauchi 4, Ippei Takahashi 4 and Chikara Ohyama 1,2 1 Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan; yosage1205@yahoo.co.jp (T....