PhosphotyrosinePyruvate KinaseProtein BindingSubstrate SpecificityNature. 2008 Mar 13;452(7184):181-6. doi: 10.1038/nature06667. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov'tdoi:10.1038/nature06667Christofk, Heather R....
Levrat and M. Cognet and A. Kahn and M. Raymondjean - 《Journal of Molecular Biology》 被引量: 319发表: 1989年 加载更多来源期刊 J.am.chem.soc August 6, 1997 研究点推荐 Pyruvate Formate-Lyase Activating Enzyme Iron−Sulfur Protein 引用走势 2000 被引量:17 ...
Inhibition of AMPK is tightly associated with metabolic perturbations upon over nutrition, yet the molecular mechanisms underlying are not clear. Here, we demonstrate the serine/threonine-protein phosphatase 6 regulatory subunit 3, SAPS3, is a negative r
Additionally, L-lactate dehydrogenase, the ultimate enzyme in the glycolytic pathway, which catalyzes the reversible conversion of pyruvate to L-lactate, could deplete its substrate present in cell culture media. Pyruvate is an additional carbon source, which improves the growth of cell lines in ...
Pyruvate dehydrogenase complex Programming Lipogenesis Adipose tissue Abbreviations ADO adenosine BSA bovine serum albumin CON control ISO isoproterenol HSL hormone-sensitive lipase KRHB Krebs–Ringer HEPES buffer MLP maternal low protein PC pyruvate carboxylase PDC pyruvate dehydrogenase complex PDK pyruvate deh...
A resonance Raman investigation into the blue chromophore of 4-hydroxyphenylpyruvate dioxygenase, a non-heme iron enzyme from Pseudomonas P. J. 874, reveals the presence of enhanced vibrations characteristic of tyrosinate coordination to the iron center. The excitation profiles for these features show...
Proteins for methyl group transfer and decarboxylation such as SAM-dependent methyltransferase, pyruvate ferredoxin oxidoreductase, and (2Fe–2S)-binding protein were also observed. Generation of reactive intermediates and their detoxification by oxidative stress-resistance protein glycolate oxidase and NADPH:...
soxA, soxB, soxC: sulfur oxidation proteins; sorA: sulfite dehydrogenase; psrA: polysulfide reductase, subunit I; qoxB: cytochrome c oxidase, caa3-type, subunit I; ccoN: cytochrome c oxidase, cbb3-type, subunit I; hhe-1 and hhe-2: bacteriohemerythrins; porA: pyruvate:ferredoxin oxireduc...
All previously described proteins involved in amylopectin metabolism such as CDPK2, GP, pyruvate phosphate dikinase (PPDK), and alpha-glucan water dikinase (WDK) are starch-binding proteins19. To test whether PP2A needs to bind to amylopectin to directly regulate starch stores, cell lysates from...
ISG15 is an interferon-stimulated, ubiquitin-like protein that can conjugate to substrate proteins (ISGylation) to counteract microbial infection, but the underlying mechanisms remain elusive. Here, we use a virus-like particle trapping technology to identify ISG15-binding proteins and discover Ring ...