16, whereas Fzs became adapted for function in eukaryotes (Fig.6). Multiple horizontal gene transfer events led to the formation of Fz1 and Fz2 from diverse TnpBs, and continuing transfers seem to also occur, as indicated by the presence...
This shows an ensemble of the 20 top-ranked modeled structures for a DNA:DNA:RNA triplex. The figure was generated by using PyMol 2.5 (Schrödinger, LLC). Source data (for a) are provided as a Source Data file. Full size image To confirm the formation of triplexes with lower ...
not significant (n.s.);p = 0.47 (RAX1),p = 0.36 (LSH2)p = 0.94 (ACR7),p = 0.77 (ACT7), one-tailed students’ t-test,n = 3 independent biological
domain 2 (PDB ID: 1BKR) was used for alignment with the generated β-III-spectrin ABD homology model. Analyses of the structures, including identification of predicted contacts for different mutated residues, and alignment, was performed with PyMOL v2.5.4 (Schrödinger, New York, NY, USA)....