Clinical Nutrition INSIGHT: December 2008 - Volume 34 - Issue 12 - p 5–7 doi: 10.1097/01.NMD.0000342338.94921.29 ArticleProtein Restriction in Kidney Disease: Is It Effective?Lomangino, Kevin Editor Abstract A
We also evaluated an eGFR decline >1 mL/min/1.73 m2, an increase in urine protein鈥揷reatinine ratio (UPCR) > 0, and an increase in UPCR >0.3 as secondary outcomes, based on SGA after the 1-year follow-up. A logistic regression (LR) model was used to calculate the odds ratio (...
(a) In control subjects the 0.01 mU/kg per min insulin infusion produced a significant ~31–34% decrease of protein degradation while it was only modestly influenced in patients with chronic kidney disease (CKD) (n=5); (b) A similar suppression of protein degradation in response to the hi...
The mRNA data were underlined by protein analysis: IL-6, IL-8, MCP-1 and VEGF protein secretion was upregulated (Supplementary Fig.S6), HGF remained unchanged. The IL-6 and IL-8 mRNA-expression and protein secretion which were downregulated in PO by the coculture with RSFC (see Fig.2d)...
Today, categorizing breast cancer is often supplemented with the tumor’s genetic markers or identification of a specific protein associated with the tumor. The identification of proteins such as HER-2 and BRCA gene expression has led to highly successful targeted therapies for these variations of br...
The cockayne syndrome B protein is essential for neuronal differentiation and neuritogenesisF Ciaffardini, S Nicolai, M Caputo, G Canu, E Paccosi, M Costantino, M Frontini, A S Balajee & L Proietti-De-Santis Cell Death & Disease volume 5, page e1268 (2014)Cite this article ...
In response to ADP binding, the Gi protein releases alpha and beta subunits that serve specific roles in the intracellular process [3]. The alpha subunit inhibits adenylyl cyclase, a protein responsible for the production of cyclic adenosine monophosphate (cAMP). Decreased cAMP production leads to ...
development and prognosis of severe disease-related AKI; while microcirculation perfusion in different parts of the kidney is different and should be assessed separately; the comprehensive assessment of renal macro-circulation and microcirculation is important for the clinical adjustment of renal hemodynamic...
under hypoxic conditions, PHD-triggered hydroxylation is inhibited, resulting in protein stabilization. VHL stabilizes MTs, including the MT axoneme of the primary cilium, thus playing a critical role in ciliogenesis. VHL loss results in a consistent loss of primary cilia, a disease categorized as...
Figure 1. Effect of postsynaptic density 95/disk-large/ZO-1 domain–containing protein (PDZK1) on absorption in the intestine and kidney. In chronic kidney disease (CKD), decreased PDZK1 impaired localization of organic cation transporter 1 (OCTN1) on the intestinal apical membrane, resulting in...