另外,分析了TCGA来自多个恶性肿瘤的RNA-seq数据,低表达有BLCA (bladder urothelial carcinoma), BRCA (breast invasive carcinoma), COAD (colon adenocarcinoma), KICH (kidney chromophobe), LUAD (lung adenocarcinoma), PRAD (prostate adenocarcinoma), READ (rectum adenocarcinoma), STAD (stomach adenocarcinoma), ...
Adenocarcinoma is the most common type of small bowel cancer constituting 32-54% of all malignant enteric tumors. Their distribution in the small intestine is regarded to have a proximal predisposition with decreasing frequency in the distal segments.K. Bhardwaj...
conducted by John Hopkins Institute USA showed a sensitivity of 95.3%, specificity of 100% and diagnostic accuracy of 98% for FNAC [107]. Other techniques like TC-99m Sestamibi uptake scan have been tried for the diagnosis of malignant masses in males [108]. Prognosis A number of variables ...
The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma. Cancer Biol Ther. 2010;10(10):1009–18. Article Google Scholar Holland SJ, Pan A, Franci C, Hu Y, Chang B, Li W, Duan M, Torneros A, Yu J, Heckrodt TJ, et al...
Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer mainly owing to its proclivity to early metastasis and the lack of effective targeted therapeutic drugs. Hence, understanding the molecular mechanisms underlying early invasion and metastasi
Note occasional moderate HDAC3 expression in prostate stroma cells. Inset: autonomous neural plexus cells exhibiting strong HDAC3 nuclear staining. (B) High-grade PIN (arrows) with strong nuclear positivity for HDAC2. (C) Microacinar prostate adenocarcinoma with only few tumour cell nuclei showing ...
An Integrin-alpha(v)beta(6)/alpha(5)beta(1)-Bitargeted Probe for the SPECT Imaging of Pancreatic Adenocarcinoma in Preclinical and Primary Clinical Studies Pancreatic adenocarcinoma (PA) is one of the deadliest human malignancies. However, early detection, prediction of surgical resectability, and ...
Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment of lung adenocarcinoma (LUAD) and are often associated with poorer clinical outcomes. This study aimed to screen for CAF-specific genes that could serve as promising t
E. Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene. Proc. Natl Acad. Sci. USA 91, 11236–11240 (1994). ADS CAS PubMed PubMed Central Google Scholar Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L. &...
We subsequently crossedARR2PB-LRIG1 Tg mice with the adenocarcinoma-prone Hi-Myc mice52to establish the LRIG1;Myc double transgenic (dTg) mice (Fig.4b). Why the Hi-Myc model? FIRST, Myc is overexpressed in the majority (~82%) of early PCa and precursor lesions called PIN (Prostate Intr...