Ispronicline (TC-1734), a brain-selective alpha4beta2 nicotine acetylcholine receptor partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. A recent study shows that the administration of TC-1734 over 10 days produces statistically significant enhancement of...
plant. To understand the consequences of this interaction on morpho-physiological parameters, we quantified biomass, chlorophyll content, proline levels, H2O2 levels, catalase and ascorbate peroxidase activity, and chromium bioaccumulation. Theoretical chemistry, utilizing molecular docking, was used to ...
where ATP was proposed to be an inhibitory neurotransmitter. In tissues precontracted by ergotamine, ATP elicited relaxation (Fig.5), but α,β-methyleneATP evoked contraction [27]. I also had a great stroke of luck at this point when, at the back of a packed freezer, I found a single ...
iLBPs share a common topology comprised of two orthogonal antiparallel beta-sheets and a helix-loop-helix motif covering the beta-barrel (Fig.1A)1,6. The binding cavity of ~1000Å3is located inside of the beta-barrel. Internal dynamics appear to have a major role in iLBP-ligand...
47, 48 Proline and glycine residues were not targetted for mutagenesis in this study to minimise the amount of structural change as they provide rigidity and flexibility respectively, to the protein backbone. Results PK1-KD cells: A stable cell line knocked-down for expression of endogenous ...
A previous XAS investigation was used to determine the atomic structure of non-OR copper-binding site in the WT HuPrP(90–231)30; in this work XAS experiments at the Cu K-edge were carried out at pH 5.5 and the structure of the binding site of both Cu(II) and Cu(I) was found to...
The modulation of metabolism and immune functions, essential in the interaction and susceptibility to infectious diseases, is also regulated by arginine [146]. Arginine is a precursor for the synthesis of proteins, nitric oxide, urea, polyamines, proline, glutamate, creatine and agmatine. The role...
By these comparisons, the majority of archaeal THI4 homologs were found to have a histidine residue conserved in the position of the active site cysteine residue (Cys205) of the yeast THI4p, with some even having a proline residue. Archaeal Thi4 ‘histidine-containing’ homologs from ...
Primary hMSCs were cultured on stiffness-controlled polyacrylamide hydrogels or silicone elastomer sheets that could be subjected to cyclic tensile strain (CTS); both substrates were collagen-I coated. hMSCs cultured for 3 days were found to spread increasingly on stiffer substrates over a physiological...
Sjögren syndrome/scleroderma autoantigen 1 (SSSCA1) was first described as an auto-antigen over-expressed in Sjögren’s syndrome and in scleroderma patients. SSSCA1 has been linked to mitosis and centromere association and as a potential marker can