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Consistent with our previous findings, we could observe a significant reduction of MEP in Plcγ1 knockdown cells (compared with control), whereas development of other lineages (CMP, GMP) remained largely unaffected (Figure 4c; Supplementary Figure S2a). Plating of lineage-depleted BM cells in ...
Opposite to IRF9, which peak score values were clearly lower than after IFNα stimulation, a higher number of annotated peaks for IRF1 could be observed in compari- son to IFNα (Fig. 1G). In line with the lack of STAT2 phos- phorylation after IFNγ treatment (Fig. 1A), no ...
Consistent with our previous findings, we could observe a significant reduction of MEP in Plcγ1 knockdown cells (compared with control), whereas development of other lineages (CMP, GMP) remained largely unaffected (Figure 4c; Supplementary Figure S2a). Plating of lineage-depleted BM cells in met...
In contrast, the frequency and total cell number of progenitor cells was significantly increased, and within this “LK cell” population, the CMP population was decreased, with an increase in the more mature GMP and MEP populations (Figures 2C and 2D). Download: Download high-res image (2MB...
Both mutant and parent F-36P-MPL cells showed TPO concentration-dependent growth; however, we observed no TPO hypersensitivity in F-36P-MPL clones 1 or 2. CMK 11-5 clone 751 demonstrated augmented STAT5 phos- phorylation compared with parent CMK11-5 cells. The growth of parent F-36P-...