administration of prazosin and a leptin antagonist. LPS increased c-fos expression in TH-positive neurons. Central administration of IL-6 and IL-1β increased c-fos immunoreactivity and serum leptin levels. Phenylephrine, an α1-adrenoceptor agonist, given i.c.v., increased the immobility time ...
ADRA1A gene knockout (KO) mice exhibited an 8–12% reduction in blood pressure depending on gene copy numbers. Phenylephrine, a subtype-nonselective agonist, raised blood pressure in KO mice, but the final arterial pressure was only 85% of that of the wild type.14 Taken together, it ...
Single aortic VSM cells (VSMCs) were freshly isolated from male and female Sprague-Dawley rats, and their contraction to phenylephrine (PHE, 10-5 M), AngII (10-7 M) and membrane-depolarization by KCl (51 mM) was measured in the absence or presence of 10-6 M 17β-estradiol (E2, ...
Introduction: This study aims to compare two vasoconstrictors: - norepinephrine and phenylephrine - in the management of dopamine- resistant septic shock... G Jain,DK Singh - 《Indian Journal of Critical Care Medicine》 被引量: 19发表: 2010年 Selective mode of action of guanidine-containing non...
7 Pressor response to phenylephrine, an ADRA1 agonist, administered intravenously was lower in Gpr143 gene-deficient (Gpr143-/y) mice than in wild-type (WT) mice. Contractile responses to phenylephrine were reduced in the aortas and mesenteric arteries isolated from Gpr143-/y mice. Intracellular...
a) Xylometazoline b) Terbutaline c) Phenylephrine d) Norepinephrine Which of the following topical decongestant agents is an alpha 2-selective agonist? a. Phenylephrine b. Xylometazoline c. Ephedrine d. Epinephrine Select the correct answer. Which of the follow...
To avoid major changes in BP that could affect the electrophysiological recordings, an automated system was developed to continually monitor BP and automatically inject small boluses of phenylephrine whenever the BP decreased past a set threshold (Figure S10). Perfusing the mice with GNE-3565 (i.v...
Which of the following topical decongestant agents is an alpha 2-selective agonist? a. Phenylephrine b. Xylometazoline c. Ephedrine d. Epinephrine Which of the following is an antiemetic agent that is related to neuroleptics? a) Metoclopramide...
As a selective α1-adrenoceptor agonist, phenylephrine has been reported to mediate cardiac hypertrophy and aortic contractile responses55. The present study found that PE could promote expression of KLK8 in neonatal myocytes. KLK8 knockdown partly reversed the PE-induced hypertrophy, whereas PE and ...
The subtype-nonselective α-agonist phenylephrine failed to induce a decrease in mRNA. It may also be noted that the subtype-selective α-adrenergic antagonists prazosin (α1) and yohimbine (α2) failed to prevent the norepinephrine-induced down-regulation. Thus, the norepinephrine-induced decrease...