If this really was the source of clozapine’s special powers, it would be a really important big breakthrough. All through residency, I kept hearing “nobody really knows why clozapine is so great” or “it probably has something to do with its weak D2 binding affinity or something”. If...
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Comparison of the in-vivo muscarinic cholinergic receptor availability in patients treated with clozapine and olanzapine. Int J Neuropsychopharmacol 2007; 10: 275–280. 43 Sarter M, Lustig C, Taylor SF. Cholinergic contributions to the cognitive symptoms of schizophrenia and the viability of ...
Before the introduction of atypical antipsychotics (such as ziprasidone, clozapine, risperidone, olanzapine, and quetiapine), pimozide was frequently used as first-line therapy for DP. However, today, many psychiatrists would choose the newer antipsychotics over pimozide because of their better safety pr...
Substance Use: Drug and alcohol misuse has been found to precede delusional disorder, especially in men[5]. Other Mental Health Disorders: In men, paranoid personality disorders like schizoid and schizotypal personality disorder tend to develop before the onset of delusional disorder[5]. ...
19. Richard T, Vanhaeverbeek M, Van Meerhaeghe A. The number needed to treat (NNT). Rev Med Brux. 2011;32:453-8. 20. Citrome L. Adjunctive aripiprazole, olanzapine, or quetiapine for major depressive disorder: an analysis of number needed to treat, number needed to harm, and ...
The atypical antipsychotic drug olanzapine increases body weight and visceral adiposity in schizophrenia. In rats, aging-associated increased body weight and visceral adiposity are reversed by administration of the pineal hormone melatonin. We asked if m
Bipolar disorder is a highly recurrent disease and has great impact on the function of patients. Depressive symptoms consist of more than 50% of life time during the illness and may lead to self harm or suicidal behaviors. Little is known about the antidepressant effects of olanzapine, an atypi...
Choline acetyltransferase variants and their influence in schizophrenia and olanzapine response. Am J Med Genet B Neuropsychiatr Genet 144B: 849–853. Nestler EJ (2005). Is there a common molecular pathway for addiction? Nat Neurosci 8: 1445–1449. Nussbaum J, Xu Q, Payne TJ, Ma JZ, Huang...
Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzipine HGGW Study Group. Arch General Psychiatry 57: 841–849. Uemura T, Green M, Corson TW, Perova T, Li PP, Warsh JJ (2011). Bcl-2 SNP rs956572 associates with disrupted intracellular ...