Herein, we provide an overview of the field of tissue-agnostic targets, in particular as it pertains to both solid and hematologic cancers, with the basic hypothesis being that if it is a solid tumor target, then it may also be a hematologic target (and vice versa)—tissue is not the ...
A CTC is a cancer cell that has detached from a solid tumor lesion and entered the peripheral blood circulation [16]. The CELLSEARCH® System is the first case that has been approved for clinical use by the Food and Drug Administration (FDA) and enables the detection and follow-up of ...
Interleukin-35 Expression in Non-Small Cell Lung Cancer is Associated with Tumor ProgressionIl-35Interleukin-35NSCLCNon-small Cell Lung Cancer... A Yuan,PC Yang,YU Chong-Jen,... - 《Am J Respir Crit Care Med》 被引量: 325发表: 2000年 Interleukin-8 messenger ribonucleic acid expression corr...
We observed nodal metastasis from cT1b tumors (solid part size > 1 cm) among proposed T categories for subsolid tumors and a solid part size is an important radiologic parameter predictive of nodal metastasis in NSCLC manifesting as a subsolid tumor. Considering the low rate of nodal metast...
This analysis identified 4 new tumor types: POLE ultramutated, microsatellite instability (MSI) hypermutated, copy-number low, and copy-number high.1 The molecular characterization data indicate that 25% of tumors classified as high-grade endometrioid by pathologists had a molecular phenotype similar ...
NSCLC, non–small-cell lung carcinoma; FDG-PET, 18-fluoro-2-deoxyglucose positron emission tomography; qPCR, quantitative polymerase chain reaction. In the group of 108 NSCLCs, 25 fresh-frozen samples were not suitable for evaluation due to sampling error (absence of tumor tissue, presence of ...
Non-small cell lung cancer (NSCLC) is a heterogeneity disease and to date, specific clinical factors and tumor stage are established as prognostic markers... CQ Zhu,MS Tsao - 《Translational Lung Cancer Research》 被引量: 38发表: 2014年 Gemcitabine-based polychemotherapy for advanced pancreatic...
Since the discovery in 2012 of rearranged during transfection proto-oncogene gene (RET) rearrangements in NSCLC, at least 12 different fusion variants have... L Salmena - Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature 被引量: 0发表: 2020年 ...
Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and the immunosuppressive nature of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components of the TME.
Fig. 1. Chemical structure of asulacrine, amsacrine and DACA. Table 1. Attributes of asulacrine. FeatureFindingsReferences Cytotoxic activity P388 leukemia, lewis lung carcinoma, human carcinoma, non-small cell lung cancer (NSCLC) Rene et al. (1997), Finlay et al. (1989), Baguley et al....