crystal‐field theorycyanideironspin statesIron man or weakling? Ligand-field strengths are conveniently expressed by the empirical spectrochemical series. Although cyanide has been deeply entrenched as a strong-field ligand, a couple of recent examples cast doubt toward the position of this ligand, ...
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(implemented by forcing each protein to have an equal node degree in the positive and negative training examples) while protein features are masked. If differential recurrence is a strong performance driver, this auditor should exhibit near-random performance. As expected, the predictions were ...
The specificity of staining was confirmed by staining with rabbit IgG (catalog no. NBP2-24891, Novus Biologicals) and mouse IgG1, kappa monoclonal (clone MOPC-21, catalog no. ab18443, Abcam) isotype controls. Digital scanned brightfield images were acquired with a NanoZoomer 2.0-HT C9600 ...
The System Builder module implemented in the Desmond algorithm was used to solvate the system using the TIP3P explicit solvent model with the OPLS_2005 force field. The model was placed in an orthorhombic water box (distance from the box face to the outermost protein/ligand atom = 10 Å, ...
However, there was a strong reduction in the amount of iron that copurified with SUMO-CTT from azide-treated cells (Fig. 2A), raising the possibility that iron is the physiological ligand of the MBD. In addition, SUMO-CTT purified from azide-treated cells was more prone to aggregation than...
Release of root exudates or downward movement of labile C in soils can lead to a ‘priming effect’—that is, a short-term increase in the rate of microbial decomposition of soil organic matter (SOM) resulting from fresh organic C input15,16(Table1), although field-based observations of th...
Hippocampal volume also had a strong negative correlation with the posterior lateral ventricle volume and strong positive correlation with the thickness of CA1 (Fig. 2k,l). Taken together, these data illustrate that removal of neuronal APOE4 protects against tau-mediated neurodegeneration and mitigates...
Using microscopy-based assays with purified proteins, we demonstrate that MKLP2 is a processive plus-end directed motor that can transport the CPC along microtubules in vitro. In cells, strong suppression of MKLP2-dependent CPC motility by expression of an MKLP2 P-loop mutant perturbs CPC ...
In further sensitivity analysis, removing this top variant still maintained significant Robust MR-Egger association (p = 0.016), with a significant intercept term suggestive of significant pleiotropy (p = 0.009) (Figure S6I). These observations provide strong clinical evidence for the role of ...