Ghrelin is a gastrointestinal neuropeptide which plays an important role in appetite, food absorption and body weight regularization. In this study we..Eizadi MDooaly HSeyedhoseini MAKhorshidi D
Ghrelin, a stomach-derived orexigenic hormone, has stimulated great interest as a potential target for obesity control. Pharmacological evidence indicates that ghrelin's effects on food intake are mediated by neuropeptide Y (NPY) and agouti-related protein (AgRP) in the central nervous system. These...
The murine postnatal leptin surge occurs within the first 4 weeks of life and is critical for neuronal projection development within hypothalamic feeding circuits. Here we describe the influence of nutritional status on the timing and magnitude of the po
For example CNR1 down- regulates anorexigenic molecules such as cocaine and amphetamine-regulated transcript in the arcuate nucleus and corticotrophin-releasing hormone (CRH) in the para- ventricular nucleus. CNR1 also upregulates orexigenic neuropeptide Y and melanin-concentrating hormone (MCH) in ...
Immunolocalization of Gpr176 was also compared with that of neuropeptide markers in the SCN. We performed double-label confocal immunohistochemistry (Supplementary Fig. 4) and found that the two non-overlapping SCN populations, Vip- and vasopressin (AVP)-ergic neurons, both appear to express Gpr17...
(SCTR), amylin receptor (AMYR), calcitonin receptor (CTR), fibroblast growth factor receptor (FGFR), neuropeptide-Y 2 receptor (NPY2R), neurotensin 1 receptor (NTSR1), non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), palmitic acid (PAL), amino acid enantiomer...
cravings (which can includesugar addiction) becoming common. For example, under-eating drives the hormone neuropeptide Y (NPY) into action, whichmakes you naturally seekmore carbohydrate-dense foods. NPY levels are naturally the highest in the morning because you’ve gone through the night without...
Islets were infected with an adenovirus encoding neuropeptide Y-venus as described previously (64). Islets were dissociated as described previously (65), and the liberated cells were allowed to adhere to poly-l-lysine-treated sterile glass slides for 24 h post-transfection. Cells were then incubat...
While JHs determine the nature of the moult, ecdysteroids trigger the moulting process and acti- vate a neuropeptide signalling cascade which in turn regulates the ecdysis sequence at the end of the moulting cycle. Models on the combined actions of hormonal and neural factors regulating insect ...
as revealed by microarray combined with gene ontology analysis16. In the same study, the most upregulated gene in the striatum ofGpr88knockout mice compared with controls was the cocaine- and amphetamine-regulated transcript (Cartpt)16, a key neuropeptide central to the control of appetite and ...