To characterize the mechanisms through which GLP-1 receptor agonists protect against diabetic kidney disease, the phase 3B FLOW Trial will assess the effects of semaglutide treatment on kidney outcomes in participants with type 2 diabetes and chronic kidney disease (NCT03819153), and this trial is ...
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The promising nature of these results has led to the first PRMT-directed targeted therapy in cancer patients (NCT02783300). This first in human, dose-escalation study will assess the pharmacokinetics, pharmacodynamics, and clinical activity of PRMT5 inhibition in subjects with advanced or recurrent ...
(NCT03819153), and this trial is expected to be completed at the end of 2024. Planned meta-analyses [42] and other studies are also underway. Studies investigating the protective effects of GLP-1 receptor agonists on cognitive dysfunction [43,44], nonalcoholic fatty liver disease (NAFLD)/non...
(NCT00882102), cytarabine (NCT02473146), and azacitidine [38]. Another example of antibody-drug conjugate therapy is the vadastuximab talirine, an anti-CD33 mAb conjugated to pyrrolobenzodiazepine, a highly potent DNA binding agent for the treatment of AML [39]. Moreover, there are also some...
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