Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD). Conditions of stress or injury induce APOE expression within neurons, but the role of neuronal APOE4 in AD pathogenesis is still unclear. Here we report the characterization of neurona...
When right-clicking a interface (that is, a Trait that uses theMolComponentEvents,MolComponentParametersorMolComponentServicesTraits), a new option appears in theMoleculesub-menu (as shown above): The title of the window indicates the name of the Type Trait as well as the type of interfaces ...
lactis Lc4. Such an effect was noted when applying the Lc4-derived CFS on two CRC cell lines - HCT116 and HT-29. We aimed to identify the main native molecule(s) responsible for this effect and to elucidate its mechanism of action. Materials and methods...
in symptomatic patients referred for cancer investigation in the NHS. The overall sensitivity and specificity were 66.3% (61.2–71.1%) and 98.4% (98.1–98.8%), respectively. Sensitivity increased with increasing age and cancer stage, from
falcip- arum-infected RBCs as well as saponin-treated parasite frac- tions (Figure S1B). At the same time, hemoglobin was detected only in intact parasite-infected RBCs and not in saponin-treated parasite fractions, confirming complete lysis of...
Mol Biochem Parasitol 184(2):90–98. https://doi.org/10.1016/j.molbiopara.2012.04.013 Article CAS PubMed Google Scholar Chaudhuri M, Ott RD, Hill GC (2006) Trypanosome alternative oxidase: from molecule to function. Trends Parasitol 22(10):484–491. https://doi.org/10.1016/j.pt....
I have seen the same result in both v1.7 and v1.9. Below is my input: molecule { C 43.447574615 4.402106285 18.442501068 Cl 43.539905548 3.305690527 19.834751129 H 43.777095795 3.891677380 17.581066132 H 42.397209167 4.711723328 18.365312576 H 44.039062500 5.304682255 18.653499603 Na 43.090690613 5.591814041 ...
SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may play a role in gynaecological cancers as well, since upregulation of SERBP1 was described in ovarian cancer recently. This is the first study to present a systematic characterisation of SERBP1 expression in human...
Gut microorganisms are solely responsible for the reduction of bilirubin to urobilinogen, potentially using the molecule as a terminal electron acceptor in anaerobic respiration. Despite the recognized role of gut microorganisms in bilirubin reduction, the gut microbial enzyme that reduces bilirubin to ur...
Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target. The binding of the spike protein with the ACE2 receptor (ACE2) of the host cell constitutes