First, precursor protein binds via TP to the cpTatC–Hcf106 receptor complex in the thylakoid membrane. Sequentially, the receptor complex bound to precursor protein is assembled with Tha4 oligomers, and a putative translocase is formed. The precursor protein is transported across the thylakoid ...
where they feed on bacteria [25]. They harbor small double membrane-bound organelles of unknown function which structurally resemble hydrogenosomes [25,26] but are probably derived from mitochondria [
Many chemotherapy treatments induce apoptosis or pyroptosis through BAK/BAX-dependent mitochondrial pathway. BAK/BAX activation causes the mitochondrial outer membrane permeabilization (MOMP), which induces the activation of pro-apoptotic caspase cascade
Mitochondria are the primary energy-generating organelles in the heart. The immense energy demands of the working heart are largely satisfied by ATP produced via mitochondrial oxidative phosphorylation (OXPHOS), from which fatty acid oxidation (FAO) contributes ~70% of the energy supply, whereas the ...
BLM does not localize to mitochondria55. Instead, increased ROS in BLM-deficient cells could be the result of the increased mitochondrial mass, but could also indicate changes in the arrangement of electron transport chain complexes in the mitochondrial membrane as a result of increased mitochondrial...
The present studies show that hydrolysis of a phosphodiester bond, most likely ATP, is a distinct, second step required to complete import of the F 1-ATPase β-subunit into the mitochondria. This step follows a membrane potential-dependent first step. We show, using an inhibitor of adenine nu...
mitochondria and cytoplasm could be responsible for ROS generation and apoptosis induction. It may undergo in case of inhibition of proline utilization for collagen biosynthesis. Although the role of collagen biosynthesis in the mechanism for switch between ATP and ROS production in mitochondria is ...
The inhibition of SDH with dimethyl malonate (DMM) may reduce the levels of mtDNA and mtROS released from damaged mitochondria, resulting in a decrease in inflammatory responses through the downregulation of pro-inflammatory cytokines and NO. 2.6. Inhibition of SDH and LPS Reduces Microglial ...
Photosynthesis occurs in chloroplasts, a type of plastid (an organelle with a membrane) that contains chlorophyll and is primarily found in plant leaves. Chloroplasts are similar tomitochondria, the energy powerhouses of cells, in that they have their own genome, or collection of genes, contained...
Carnation Italian ringspot virus (CIRV) is a positive-strand RNA virus that causes massive structural alterations of mitochondria in infected host cells, the most conspicuous being the formation of numerous internal vesicles/spherules that are derived from the mitochondrial outer membrane and serve as...