MiR-214 belongs to a family of microRNA (small, highly conserved noncoding RNA molecules) precursors that play a pivotal role in biological functions, such as cellular function, tissue development, tissue homeostasis, and pathogenesis of diseases. Recently, miR-214 emerged as a critical regulator ...
miR-541 has been identified as a tumor suppressor in hepatocellular carcinoma and a regulator of fibrotic disease, such as lung fibrosis and renal fibrosis. However, its role in liver cirrhosis has not been reported. Methods: Real-time PCR was used to detect miR-541 expression in the liver ...
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MicroRNA-145 (miR-145) expression is downregulated in several human cancers, but its clinical and functional relevance to ovarian carcinoma has not yet been elucidated. This study addressed the hypothesis that miR-145 serves as a prognostic biomarker and a tumor suppressor that regulates the express...
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et al. miR-130a expression is related to aortic dilation in bicuspid aortic valve children. Pediatr Res 95, 1741–1748 (2024). https://doi.org/10.1038/s41390-024-03018-5 Download citation Received12 April 2023 Revised03 October 2023 Accepted26 December 2023 Published26 January 2024 Issue Date...
Through bioinformatics screening, one targeted DPYD MicroRNA (miRNA) miR-134 was selected, and we discovered by luciferase reporter assay that this miRNA bound to the untranslated region (UTR) of DPYD mRNA. Then, the correlation between miR-134 and DPYD was investigated. Our results reveal that...
We could show that miR451, one of the micorRNAs of the miR144/451 cluster, supports erythroid differentiation. We found that expression of miR451 is repressed by the RUNX1/ETO fusion protein, resulting in up regulation of miR451 target genes. Our data support the notion that RUNX1 ...
However, the possible roles of miR-768-3p in the pathological changes of lung carcinomas are still unknown. The aim of the present study was to investigate the expression and possible effects of miR-768-3p in human non-small cell lung carcinomas (NSCLC). Eighty-three NSCLC patients ...
CONCLUSION: These findings suggest that the upregulation of miR-584 by Pg in OBA-9 inhibits the anti-inflammatory effects of hLf via the suppression of LfR. 展开 关键词: Epithelial cells inflammation interleukin‐8 microRNAs periodontitis Porphyromonas gingivalis ...