Centrosome amplification has been extensively associated with cancer. Cancer cells with extra centrosomes have the ability to cluster the extra centrosomes and divide in a bipolar fashion. Although a number of proteins have been shown to be involved in c
In both human Lx2 stellate cells and primary mouse HSCs (mHSCs), we found that DHA reduced HSC proliferation and expression of pro-fibrogenic factors (COL1A1, αSMA and PDGFRβ) in a dose-dependent manner (Supplementary Fig. 2). In addition, DHA markedly enhanced the expression of ADRP, ...
For human GIPC3 continuous cDNA could not be obtained, two independent clones (Dharmacon, MHS6278-211687736, clone ID: 40125863) exhibited an approximately 20 bp deletion in the GC rich 5′ part. Instead, for the 5’ 240 bp region, single-stranded DNA designed with reduced GC content in ...
with lowest library size of 3678 reads. We then examined the association of alpha and beta diversity (usingveganR package) and abundance of taxa (using DESeq2, stabsel, GeneSelector R packages, and LEfSE galaxy portal [54,55,56]) at each site. To compare community characteristics...
We found that both scores concurrently classified the patients into two groups—non- progressors (fibrosis stages F0 ¼ no fibrosis; F1 ¼ portal fibrosis without bridges; F2 ¼ portal fibrosis with rare bridges) and progressors (fibrosis stages F3 ¼ numerous bridges without cirrhosis; F4...
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